Ketone bodies promote epididymal white adipose expansion to alleviate liver steatosis in response to a ketogenic diet.

Liver can sense the nutrient status and send signals to other organs to regulate overall metabolic homoeostasis. Herein, we demonstrate that ketone bodies act as signals released from the liver that specifically determine the distribution of excess lipid in epididymal white adipose tissue (eWAT) when exposed to a ketogenic diet (KD). An acute KD can immediately result in excess lipid deposition in the liver. Subsequently, the liver sends the ketone body ß-hydroxybutyrate (BHB) to regulate white adipose expansion, including adipogenesis and lipogenesis, to alleviate hepatic lipid accumulation. When ketone bodies are depleted by deleting 3-hydroxy-3-methylglutaryl-CoA synthase 2 gene in the liver, the enhanced lipid deposition in eWAT but not in inguinal white adipose tissue is preferentially blocked, while lipid accumulation in liver is not alleviated. Mechanistically, ketone body BHB can significantly decrease lysine acetylation of peroxisome proliferator-activated receptor gamma in eWAT, causing enhanced activity of peroxisome proliferator-activated receptor gamma, the key adipogenic transcription factor. These observations suggest that the liver senses metabolic stress first and sends a corresponding signal, that is, ketone body BHB, to specifically promote eWAT expansion to adapt to metabolic challenges.

Co-delivery of a tumor microenvironment-responsive disulfiram prodrug and CuO2 nanoparticles for efficient cancer treatment.

Disulfiram (DSF) has been used as a hangover drug for more than seven decades and was found to have potential in cancer treatment, especially mediated by copper. However, the uncoordinated delivery of disulfiram with copper and the instability of disulfiram limit its further applications. Herein, we synthesize a DSF prodrug using a simple strategy that could be activated in a specific tumor microenvironment. Poly amino acids are used as a platform to bind the DSF prodrug through the B-N interaction and encapsulate CuO2 nanoparticles (NPs), obtaining a functional nanoplatform Cu@P-B. In the acidic tumor microenvironment, the loaded CuO2 NPs will produce Cu2+ and cause oxidative stress in cells. At the same time, the increased reactive oxygen species (ROS) will accelerate the release and activation of the DSF prodrug and further chelate the released Cu2+ to produce the noxious copper diethyldithiocarbamate complex, which causes cell apoptosis effectively. Cytotoxicity tests show that the DSF prodrug could effectively kill cancer cells with only a small amount of Cu2+ (0.18 µg mL-1), inhibiting the migration and invasion of tumor cells. In vitro and in vivo experiments have demonstrated that this functional nanoplatform could kill tumor cells effectively with limited toxic side effects, showing a new perspective in DSF prodrug design and cancer treatment.

Optoelectronic Metasurface for Free-Space Optical-Microwave Interactions.

Photon-electron interactions are essential for many areas such as energy conversion, signal processing, and emerging quantum science. However, the current demonstrations are typically targeted to fiber and on-chip applications and lack of study in wave space. Here, we introduce a concept of optoelectronic metasurface that is capable of realizing direct and efficient optical-microwave interactions in free space. The optoelectronic metasurface is realized via a hybrid integration of microwave resonant meta-structures with a photoresponsive material. As a proof of concept, we construct an ultrathin optoelectronic metasurface using photodiodes that is bias free, which is modeled and analyzed theoretically by using the light-driven electronic excitation principle and microwave network theory. The incident laser and microwave from the free space will interact with the photodiode-based metasurface simultaneously and generate strong laser-microwave coupling, where the phase of output microwave depends on the input laser intensity. We experimentally verify that the reflected microwave phase of the optoelectronic metasurface decreases as the incident laser power becomes large, providing a distinct strategy to control the vector fields by the power intensity. Our results offer fundamentally new understanding of the metasurface capabilities and the wave-matter interactions in hybrid materials.

A metasurface-based light-to-microwave transmitter for hybrid wireless communications.

Signal conversion plays an important role in many applications such as communication, sensing, and imaging. Realizing signal conversion between optical and microwave frequencies is a crucial step to construct hybrid communication systems that combine both optical and microwave wireless technologies to achieve better features, which are highly desirable in the future wireless communications. However, such a signal conversion process typically requires a complicated relay to perform multiple operations, which will consume additional hardware/time/energy resources. Here, we report a light-to-microwave transmitter based on the time-varying and programmable metasurface integrated with a high-speed photoelectric detection circuit into a hybrid. Such a transmitter can convert a light intensity signal to two microwave binary frequency shift keying signals by using the dispersion characteristics of the metasurface to implement the frequency division multiplexing. To illustrate the metasurface-based transmitter, a hybrid wireless communication system that allows dual-channel data transmissions in a light-to-microwave link is demonstrated, and the experimental results show that two different videos can be transmitted and received simultaneously and independently. Our metasurface-enabled signal conversion solution may enrich the functionalities of metasurfaces, and could also stimulate new information-oriented applications.

Self-adaptive metasurface platform based on computer vision.

Programmable metasurfaces allow real-time electromagnetic (EM) manipulation in a digital manner, showing great potential to construct advanced multifunctional EM devices. However, the current programmable metasurfaces typically need human participation to achieve various EM functions. In this Letter, we propose, design, and construct a self-adaptive metasurface platform that can achieve beam control automatically based on image recognition. Such a platform is composed of a metasurface with 36×36 active units, a single-board computer, and two independent cameras that can detect the position of the objects. The single-board computer, Raspberry Pi, is used to calculate the information of the objects and generate the coding sequences to control the digital metasurface based on a low complexity binocular localization algorithm. Such a smart metasurface platform can generate different beams according to the location of the receiver and can be used as intelligent antennas in future communications and radars.

Smart Doppler Cloak Operating in Broad Band and Full Polarizations.

Invisibility cloaks, a class of attractive devices that can hide objects from external observers, have become practical reality owing to the advent of metamaterials. In previous cloaking schemes, almost all demonstrated cloaks are time-invariant and are investigated in the system that is motionless, and hence they are limited to hide stationary objects. In addition, the current cloaks are typically static or require manual operation to achieve dynamic cloaking. Here, a smart Doppler cloak operating in broadband and full polarizations is reported, which consists of a time-modulated reflective metasurface and a sensing-feedback time-varying electronic control system. Experimental results show that the smart Doppler cloak is able to respond self-adaptively and rapidly to the ever-changing velocity of moving objects and then cancel different Doppler shifts in real time, without any human intervention. Moreover, the wideband and polarization-insensitive features enable the cloak to be more robust and practical. To illustrate the capabilities of the proposed approach, the smart Doppler cloak is measured in three scenarios with two different groups of linearly-polarized incidences at 3.3 and 4.9 GHz, and one group circularly-polarized incidences at 6.0 GHz, respectively.

Polarization-Controlled Dual-Programmable Metasurfaces.

Programmable metasurfaces allow dynamic and real-time control of electromagnetic (EM) waves in subwavelength resolution, holding extraordinary potentials to establish meta-systems. Achieving independent and real-time controls of orthogonally-polarized EM waves via the programmable metasurface is attractive for many applications, but remains considerably challenging. Here, a polarization-controlled dual-programmable metasurface (PDPM) with modular control circuits is proposed, which enables a dibit encoding capability in modifying the phase profiles of x- and y-polarized waves individually. The constructed extended interface circuit is able to extend the number of control interfaces from a field programmable gate array by orders of magnitude and also possesses memory function, which enhance hugely the rewritability, scalability, reliability, and stability of PDPM. As a proof-of-concept, a wave-based exclusive-OR logic gate platform for spin control of circularly-polarized waves, a fixed-frequency wide-angle dual-beam scanning system, and a dual-polarized shared-aperture antenna are demonstrated using a single PDPM. The proposed PDPM opens up avenues for realizing more advanced and integrated multifunctional devices and systems that have two independent polarization-controlled signal channels, which may find many applications in future-oriented intelligent communication, imaging, and computing technologies.

Infrared-controlled programmable metasurface.

Programmable metasurface enables controlling electromagnetic (EM) waves in real time. By programming the states of active device embedded in metasurface element, the EM properties of the digital metasurface can be changed quickly without redesigning their structures. However, large numbers of long-distance wires are required to connect the programmable metasurface to provide the coded signals from field programmable gate array (FPGA) when controlling the metasurface at a long distance, which is complicated and inconvenient. Here, we propose an infrared-controlled programmable metasurface that can be programmed remotely. The infrared transceiver is able to switch the coding sequences stored in the FPGA controller, thus controlling the voltage on the varactors integrated in the metasurface. Experiment is performed at microwave frequencies, and the measured results verify that the scattering beams of the metasurface sample can be changed remotely by using infrared ray. The proposed infrared-controlled programmable metasurface opens up avenues for constructing a new class of remotely-tuning dynamic metasurfaces.

Light-Controllable Digital Coding Metasurfaces.

Since the advent of digital coding metamaterials, a new paradigm is unfolded to sample, compute and program electromagnetic waves in real time with one physical configuration. However, one inconvenient truth is that actively tunable building blocks such as diodes, varactors, and biased lines must be individually controlled by a computer-assisted field programmable gate array and physically connected by electrical wires to the power suppliers. This issue becomes more formidable when more elements are needed for more advanced and multitasked metadevices and metasystems. Here, a remote-mode metasurface is proposed and realized that is addressed and tuned by illuminating light. By tuning the intensity of light-emitting diode light, a digital coding metasurface composed of such light-addressable elements enables dynamically reconfigurable radiation beams in a control-circuitry-free way. Experimental demonstration is validated at microwave frequencies. The proposed dynamical remote-tuning metasurface paves a way for constructing unprecedented digital metasurfaces in a noncontact remote fashion.

Controlling Radiation Beams by Low-Profile Planar Antenna Arrays with Coding Elements.

Beam diversity enables antenna arrays to play important roles in radar, communications, imaging, and next-generation wireless systems. However, achieving flexible control of beams in a low-cost way is still very challenging. Here, we propose low-profile planar antenna arrays with coding elements to control and engineer radiation patterns more freely and flexibly. The proposed planar antenna array consists of binary radiating elements which are characterized by digital codes "0" and "1". By designing spatial coding patterns of the radiating elements, multifarious functionalities can be well realized, such as beam splitting, beam scanning, and beam deflection. More importantly, coding metasurfaces can be properly arranged around the digital radiating elements to reduce the radar cross section of the antenna, while the radiation performance is well preserved. The low-profile, high-gain, lightweight digital antenna arrays are verified numerically and experimentally in the microwave band. The proposed digital coding planar antenna arrays derive a new paradigm to control the radiation patterns in low-overhead and advanced digital design fashions and offer promising applications in multitasked and intelligent antenna devices and new information systems.