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A review of ERGIC-53: its structure, functions, regulation and relations with diseases.

Zhang, Yong Ci; Zhou, Yuan; Yang, Chun Zheng; Xiong, D S.

Histol Histopathol ; 24(9): 1193-204, 2009 09.

Article in English | MEDLINE | ID: mdl-19609866

ABSTRACT

ERGIC-53 is a type I transmembrane protein. It includes an N-terminal signal sequence, a carbohydrate recognition domain, which is calcium-dependent and pH-sensitive, a stalk region, a transmembrane domain, and a short cytoplasmic domain; ERGIC-53 mainly acts as a receptor of a limited number of glycoprotein and transports them from ER to ERGIC and Golgi, meanwhile it has a secondary glycoprotein quality control function. Recent research has revealed that UPR, heat shock and VIPL may regulate the expression of ERGIC-53. F5F8D, and some ER storage diseases have relationship with ERGIC-53.

Subject(s)

Mannose-Binding Lectins/chemistry , Mannose-Binding Lectins/metabolism , Membrane Proteins/chemistry , Membrane Proteins/metabolism , Blood Coagulation Disorders, Inherited/genetics , Endoplasmic Reticulum/metabolism , Factor V/genetics , Factor VIII/genetics , Gene Expression Regulation , Genes, Recessive , Glycoproteins/metabolism , Golgi Apparatus/metabolism , Mannose-Binding Lectins/genetics , Membrane Proteins/genetics , Protein Binding , Protein Sorting Signals , Protein Structure, Tertiary , Protein Transport , Vesicular Transport Proteins/metabolism

ABSTRACT

Subject(s)

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