Reactivity and regioselectivity in Diels-Alder reactions of anion encapsulated fullerenes.

Encapsulation and surface chemical modification are methodologies to enhance the properties of fullerenes for various applications. Herein, density functional theory calculations are performed to study the Diels-Alder (DA) reactivity of anion encapsulated C60, including [X@C60]- (X = F, Cl, Br, or I), [S@C60]2-, and [N@C60]3-. Computational results reveal that encapsulated Cl-, Br-, I-, or S2- anions are located close to the center of the C60 molecule; however, encapsulated F- is displaced from the center. Encapsulated N3- bonds to the inner surface of the carbon cage, which leads to a negative charge transfer to the C60. In [N@C60]3-, C-C bonds near to the encapsulated N atom are more reactive. Our calculations reveal that encapsulated halogen or S anions decrease the DA reactivity because of the stronger closed-shell repulsion of the encapsulated anion. However, encapsulated N3- increases the DA reactivity. The higher distortion energy of the halogen- or S2--anion encapsulated C60 leads to lower reactivity of the 6-5 bond. Opposite regioselectivity of the DA reaction with [N@C60]3- is attributed to distortion energy of the cyclopentadiene (CPD) moiety. The asymmetrical transition state geometry leads to a lower distortion energy of the CPD moiety.

Theoretical Study on the Reactivity and Regioselectivity of the Diels-Alder Reaction of Fullerene: Effects of Charges and Encapsulated Lanthanum on the Bis-Functionalization of C70.

Bis-adducts of fullerenes are important for both material and biological science. The first added substituent greatly impacts the reactivity and regioselectivity of fullerene. What determines the bond reactivity and how to control the regioselectivity are two crucial questions in synthesizing bis-adduct of C70. Recently, an unexpected 12 o'clock isomer of anthracene bis-adduct of C70 was prepared with high yield by the Diels-Alder (DA) reaction although three possible isomers (12, 2, and 5 o'clock isomers) may be formed. In the current study, the beneath mechanism is systematically investigated by density functional theory methods. Moreover, effects of charges and encapsulated lanthanum atom on the regioselectivity are reported. The computational results successfully rationalize experimental observations by Venkata et al. A possible way to change the regioselectivity of DA reaction is put forward. The kinetical promotion effect of an encapsulated La atom on the 12 o'clock reaction is elucidated.