ABSTRACT
BACKGROUND: Cronkhite-Canada syndrome (CCS) is a disease of unknown etiology characterized by the presence of multiple gastrointestinal polyps, chronic diarrhea, loss of appetite, alopecia, onychodystrophy, and cutaneous hyperpigmentation. CCS is a rare disease with an incidence rate of 1 per million. Clinicians are not aware of this disease, and the discovery of gastrointestinal polyps is often a starting point for the diagnosis of this disease. By analyzing the endoscopic and pathological characteristics of CCS, this study aims to deepen our understanding of gastrointestinal polyposis and facilitate early diagnosis of CCS. METHODS: We screened databases, including the Chinese Biomedical Literature Database (CBM Web), the China Academic Journals Fulltext Database (CJFD), and PubMed for CCS cases reported from January 2010 to January 2020, and conducted a retrospective analysis of endoscopic and pathological characteristics of these cases. RESULTS: The endoscopic data of the 76 retrieved cases revealed that CCS is gastrointestinal polyposis with the intensive and confluent distribution. The greater the number of polyps and the higher their distribution, the brighter their color. A pathological assessment revealed that both gastric polyps and intestinal polyps are mainly juvenile hamartomatous polyps and have a high malignant transformation rate. Interstitial edema, eosinophil infiltration, and cystic dilation of glands are common features of CCS polyps, distinguishing them from other gastrointestinal polyposis syndromes. CONCLUSION: CCS is a polyp disease different from other gastrointestinal polyposis. Analysis of its endoscopic and pathological characteristics can contribute to the understanding and early diagnosis of the disease.
Subject(s)
Colorectal Neoplasms , Intestinal Polyposis , Stomach Neoplasms , Canada , Humans , Intestinal Polyposis/diagnosis , Intestinal Polyposis/pathology , Intestinal Polyps , Retrospective StudiesABSTRACT
Colorectal cancer (CRC) is one of the most common cancers worldwide. B cell-associated protein 31 (BAP31) was shown to participate in the apoptosis, and to be an immunotherapy target and a, prognostic factor for cancer, but its role in CRC has not been elucidated. In this study, we examined the expression of BAP31 in CRC to evaluate its prognostic values. We investigated the BAP31 expression level in 142 tissues (108 CRC and 17 paired human adjacent normal mucosa, and 17 liver metastatic CRC tissues) from 108 patients, using tissue microarray-based immunohistochemistry. We further investigated the association between BAP31 expression and overall survival (OS) and disease-free survival (DFS) in 77 CRC patients using Kaplan-Meier analysis. Univariate and multivariate Cox regression analyses were applied to evaluate the potential prognostic value of BAP31 in CRC patients. BAP31 expression level was significantly increased in CRC tissues (pâ¯=â¯0.0014) and liver metastatic CRC tissues (pâ¯<â¯0.0001) compared with corresponding adjacent normal mucosa. BAP31 expression was also significantly increased in liver metastatic CRC tissues compared with corresponding primary CRC tissues (pâ¯=â¯0.0116). Kaplan-Meier analyses showed that CRC patients with low BAP31 expression had significantly lower survival rate (pâ¯=â¯0.001) and lower disease-free survival rate (Pâ¯=â¯0.009). Furthermore, multivariate Cox analysis showed that BAP31 was an independent prognostic factor for OS (hazard ratioâ¯=â¯0.410, 95% confidence intervalâ¯=â¯0.195-0.862, pâ¯=â¯0.019). CONCLUSIONS: Our study demonstrated that BAP31 is a potential prognostic marker for CRC patients after surgery.
Subject(s)
Colorectal Neoplasms/diagnosis , Colorectal Neoplasms/pathology , Membrane Proteins/metabolism , Adult , Aged , Aged, 80 and over , Biomarkers, Tumor/analysis , Colorectal Neoplasms/surgery , Disease-Free Survival , Female , Humans , Immunohistochemistry/methods , Male , Middle Aged , Prognosis , Proportional Hazards Models , Tissue Array Analysis/methodsSubject(s)
Histiocytosis, Sinus/pathology , Lung Diseases/pathology , S100 Proteins/metabolism , Adult , Antigens, CD/metabolism , Antigens, Differentiation, Myelomonocytic/metabolism , Carcinoma, Giant Cell/metabolism , Carcinoma, Giant Cell/pathology , Diagnosis, Differential , Granuloma, Plasma Cell/metabolism , Granuloma, Plasma Cell/pathology , Histiocytosis, Sinus/metabolism , Histiocytosis, Sinus/surgery , Humans , Immunohistochemistry , Lung Diseases/metabolism , Lung Diseases/surgery , Lung Neoplasms/metabolism , Lung Neoplasms/pathology , Male , Pneumonectomy/methods , Vimentin/metabolismABSTRACT
OBJECTIVE: To study a new effective approach which repairs large defects of skin and soft tissue in neck and face. METHOD: This procedure accomplishes repetitive sub-platysmal expansion to form large musculocutaneous flap with underlying pedicel. The surgeon slides it toward neck and face to repair the defects of skin and soft tissue. RESULT: Eleven patients, who had such defects in neck, face, cheek, chin or submental skin and soft tissue, underwent this treatment. All the flaps survive with no complications of blood supply deficiency or necrosis. The short-term and long-term results are both satisfying. CONCLUSION: This method, making repetitive sub-platysmal expansion to form musculocutaneous flap and then slide it toward neck/face to repair large defects of skin and soft tissue, proves to be safe and reliable. And appropriate cases and strict operations are important.
