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Org Lett ; 19(10): 2634-2637, 2017 05 19.
Article in English | MEDLINE | ID: mdl-28481099

ABSTRACT

The enantioselective cross-aldol reaction between o-hydroxyacetophenones and trifluoromethyl ketones catalyzed by chiral thiourea organocatalysts is reported. Gram-scale synthesis of the cross-aldol product was carried out, with no decrease in the yield and enantioselectivity. Furthermore, the cross-aldol products thus prepared were used in the preparation of medicinally interesting 3,5-diaryl-5-trifluoromethyl-2-isoxazoline and ß-trifluoromethyl-ß-tertiary hydroxy acid ester with high yield and enantiopurity.

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