ABSTRACT
We perform Q Lg tomography for the northeastern part of North America. Vertical broadband seismograms of 473 crustal earthquakes recorded by 302 stations are processed to extract the Lg amplitude spectra. Tomographic inversions are independently conducted at 58 discrete frequencies distributed evenly in log space between 0.1 and 20.0 Hz. This relatively large dataset with good ray coverage allows us to image lateral variation of the crustal attenuation over the region. Obtained Q Lg maps at broadband and individual frequencies provide new insights into the crustal attenuation of the region and its relationship to geological structures and past tectonic activity in the area. The Q Lg shows more uniform values over the older, colder, and drier Canadian Shield, in contrast to higher variations in the younger margins. Results confirm the correlation of large-scale variations with crustal geological features in the area. Existence of low-velocity anomalies, thick sediments, volcanic rocks, and thin oceanic crust are potential sources of observed anomalies. The mean Q values are inversely correlated with average heat flow/generation for main geological provinces.
ABSTRACT
Wogonoside, a bioactive flavonoid extracted from the root of Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory and antioxidant effects. In this study, we examined the protective effects of wogonoside against lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-induced liver injury in mice. Mice were given an intraperitoneal injection of wogonoside 1h before LPS and d-GalN treatment. The results showed that wogonoside inhibited the production of serum Alanine transaminase (ALT), Aspartate aminotransferase (AST), IL-1ß, TNF-α, and hepatic malondialdehyde (MDA) content induced by LPS/GalN. In addition, wogonoside promoted the expression of Nrf2, NQO-1, GCLC, and HO-1. Wogonoside inhibited the expression of hepatic NLRP3, ASC, caspase-1, and IL-1ß induced by LPS/GalN. In conclusion, these results suggest that wogonoside protects against LPS/GalN-induced acute liver injury by activating Nrf2 and inhibiting NLRP3 inflammasome activation.