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J Asian Nat Prod Res ; 26(6): 765-771, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38373226

ABSTRACT

To clarify the chemical basis of the total alkaloids of Uncaria rhynchophylla, HPLC-VWD chromatogram of total alkaloids was established. Under its guidance, modern chromatographic and spectroscopic techniques were used to track, isolate and identify the representative principal components. As a result, one new monoterpenoid indole alkaloid, 3S,15S-N4-methoxymethyl-geissoschizine methyl ether (1), together with 20 known alkaloids (2-21), and 5 other known compounds (22-26) were obtained. Meanwhile, sixteen characteristic peaks were identified from the total alkaloids using HPLC analysis. Then, the anti-neuroinflammatory effect of compounds 1-21 was assessed through inhibiting nitric ---oxide (NO) production in lipopolysaccharide (LPS)-induced BV-2 microglial cells. Among them, compounds 1, 3, 7, 8, 11, 12, 19 and 21 showed potent inhibitory activities with IC50 values of 5.87-76.78 µM.


Subject(s)
Alkaloids , Anti-Inflammatory Agents , Indole Alkaloids , Lipopolysaccharides , Microglia , Nitric Oxide , Uncaria , Uncaria/chemistry , Molecular Structure , Alkaloids/pharmacology , Alkaloids/chemistry , Nitric Oxide/antagonists & inhibitors , Nitric Oxide/biosynthesis , Anti-Inflammatory Agents/pharmacology , Anti-Inflammatory Agents/chemistry , Lipopolysaccharides/pharmacology , Microglia/drug effects , Animals , Mice , Chromatography, High Pressure Liquid , Secologanin Tryptamine Alkaloids/pharmacology , Secologanin Tryptamine Alkaloids/chemistry
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