ABSTRACT
Inspired by marine mussel, catechol-containing materials, such as adhesives, self-healing hydrogels, and antifouling coatings, have been developed with wide applications in chemical, biomedical, and electronics industries. Conventionally, petrochemicals or organic solvents are widely used for preparation and dissolution of adhesives, which makes the adhesives are not eco-friendly and biocompatible. To develop environmentally friendly and biocompatible adhesives with desired properties, here we report catechol-containing cellulose-based tissue adhesives, synthesized by incorporating catechol groups onto cellulose. The structures of the adhesives with different catechol contents were analyzed by UV-vis spectroscopy, Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (1H NMR) spectroscopy. The adhesion strengths were examined using porcine skin by lap shear tensile tests. The adhesion strength of the as-prepared adhesive with catechol content of 16.5 mol% was 20.0 kPa. Fe3+ was used as crosslinker to enhance the adhesion strength and accelerate the solidification of adhesives. Through the Fe3+-catechol coordination, the adhesion strength of adhesive was increased to 88.0 kPa, showing strong mechanical strength compared to the fibrin adhesive. NIH 3T3 cells test demonstrates that the adhesive is favorable for cell attachment and proliferation, possessing excellent biocompatibility. The catechol-containing cellulose-based adhesive has promising application in bioengineering field.
Subject(s)
Biocompatible Materials/chemistry , Biomimetics , Bivalvia/chemistry , Cellulose/chemistry , Materials Testing , Metals/chemistry , Tissue Adhesives/chemistry , Animals , Catechols/chemistry , Cell Survival , Mice , NIH 3T3 Cells , Swine , ThermogravimetryABSTRACT
Self-healing gels based on reshuffling disulfide bonds have attracted great attention due to their ability to restore structure and mechanical properties after damage. In this work, self-healing gels with different cellulose nanocrystals (CNC) contents were prepared by embedding the thiuram disulfide bonds into gels via polyaddition. By the reshuffling of thiuram disulfide bonds, the CNC-containing gels repair the crack and recover mechanical properties rapidly under visible light in air. The thiuram disulfide-functionalized gels with a CNC content of 2.2% are highly stretchable and can be stretched approximately 42.6 times of their original length. Our results provide useful approaches for the preparation of dynamic CNC-containing gels with implications in many related engineering applications.
