ABSTRACT
PURPOSE: To explore the effects of the fast-track surgery (FTS) approach during the perioperative period of ophthalmic surgery in pediatric patients. METHODS: A bidirectional cohort design was applied in this study. The traditional nursing mode was followed in relation to 40 pediatric patients admitted for ophthalmic surgery in March 2018 (control group), whereas the FTS mode was followed with regard to 40 pediatric patients admitted for ophthalmic surgery in April 2018 (observation group). The effects of the FTS mode were determined by comparing the postoperative pain score, restlessness score, and the incidence of postoperative nausea and vomiting between the two groups. RESULTS: The pain and restlessness scores of the patients at 4hours after surgery in the observation group were significantly decreased compared with those in the control group (P<0.01). The incidence of postoperative nausea and vomiting in the observation group was also slightly lower than that in the control group (P>0.05). CONCLUSION: A perioperative FTS-based nursing mode can effectively alleviate the postoperative pain and restlessness of pediatric patients without increasing their stress response.
ABSTRACT
Qian-Hu is a well-known traditional Chinese medicine used for the treatment of respiratory diseases and pulmonary hypertension. We compared the relaxant effects of pyranocoumarin compounds, including (+)-praeruptorin A (Pra-C), Pd-Ia (=(+/-)-praeruptorin A), pteryxin, peucedanocoumarin II (P-II) and 8-methoxy-psoralen (8-MOP) purified from Bai-Hua Qian-Hu (BQ) in isolated rabbit tracheas and pulmonary arteries. Pra-C, pteryxin and Pd-Ia produced significant relaxant effects in tracheal preparations constricted with 40 mM KCl or 10 microM acetylcholine. The relaxant response to Pra-C, pteryxin or Pd-Ia in preparations constricted with KCl was significantly more potent than that in preparations constricted with acetylcholine. Pra-C, pteryxin or Pd-Ia at a concentration of 30 microM completely relaxed tracheas constricted with 40 mM KCl, whereas P-II at the same concentration showed only partial relaxation. In pulmonary arterial preparations, 8-MOP produced a significant relaxant effect on contractions by 10 microM phenylephrine, without any effect on the contraction by 40 mM KCl. These results suggest that Pd-Ia, pteryxin and Pra-C for their calcium antagonistic action, and 8-MOP for its inhibitory effect on contraction induced by phenylephrine, may be the active principles of BQ for relaxing the smooth muscle of tracheas and pulmonary arteries, and the principle may produce a synergistic effect.
Subject(s)
Bronchodilator Agents/pharmacology , Coumarins/pharmacology , Drugs, Chinese Herbal/pharmacology , Plants, Medicinal/chemistry , Pulmonary Artery/drug effects , Trachea/drug effects , Vasodilator Agents/pharmacology , Animals , Coumarins/isolation & purification , Drugs, Chinese Herbal/chemistry , Female , In Vitro Techniques , Male , Methoxsalen/pharmacology , Pulmonary Artery/physiology , Rabbits , Trachea/physiologySubject(s)
Calcium-Transporting ATPases/metabolism , Harringtonines/pharmacology , Malondialdehyde/metabolism , Myocardium/metabolism , Sarcoplasmic Reticulum/metabolism , Animals , Lipid Bilayers/metabolism , Lipid Peroxidation/drug effects , Male , Membrane Lipids/metabolism , Phospholipids/metabolism , Rats , ViscosityABSTRACT
The contractions of isolated rabbit trachea smooth muscles by acetylcholine and potassium chloride were attenuated by petroleum ether extract of Peucedanum praeruptorum pretreatment. The dose-effect curve of acetylcholine was shifted to the right, and the maximal response was diminished. The effect was non-competitive and dose-dependent.
