1.
Org Biomol Chem
; 7(18): 3663-5, 2009 Sep 21.
Article
in English
| MEDLINE
| ID: mdl-19707669
ABSTRACT
The enantioselective synthesis of Anomala osakana pheromone and Janus integer pheromone has been achieved without using any protecting groups. The synthesis involved using an asymmetric alkynylation to obtain gamma-hydroxy-alpha,beta-acetylenic esters with high ee (84%) and yields ( approximately 80%), followed by selective hydrogenation and lactonization in high overall yields (87% and 89%).