Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Publication year range
1.
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue ; 33(6): 765-768, 2021 Jun.
Article in Chinese | MEDLINE | ID: mdl-34296704

ABSTRACT

Sepsis is a critical illness with high morbidity and mortality. Anaerobic glycolysis plays an important role in the pathogenesis of sepsis. Pyruvate dehydrogenase complex (PDHC) serves as a key regulator during sepsis. With PDHC dephosphorylation and deacetylation, PDHC activity is upregulated, allowing pyruvate translocate to mitochondria in aerobic condition, preceding the production of acetyl-CoA to accelerate aerobic oxidation. Activation of PDHC improves the prognosis of sepsis through regulating the balance of lactate, release of inflammatory factors and energy metabolism. A variety of remedies can improve the prognosis of patients with sepsis by up-regulating the activity of PDHC, including dichloroacetate (DCA), vitamin B1, milrinone, tumor necrosis factor binding protein, and ciprofloxacin.This article reviews the role and the regulatory mechanism of PDHC and signal pathway in the sepsis metabolism, in order to innovate treatment for sepsis and multiple organ dysfunction.


Subject(s)
Pyruvate Dehydrogenase Complex , Sepsis , Energy Metabolism , Glycolysis , Humans , Pyruvate Dehydrogenase Complex/metabolism , Pyruvates , Sepsis/drug therapy
2.
Clin Rheumatol ; 37(7): 2001-2005, 2018 Jul.
Article in English | MEDLINE | ID: mdl-29717396

ABSTRACT

Acute fibrinous and organizing pneumonia (AFOP) is a new histopathological pattern of acute lung injury first described by Beasley et al. in 2002. Hallmarks of pathological findings are characterized by the presence of intra-alveolar fibrin in the form of fibrin "balls" within the alveolar spaces and organizing pneumonia with a patchy distribution. Patients with AFOP may have an acute or subacute clinical presentation. Although the pathogenesis of AFOP is not fully elucidated, it may be associated with autoimmune diseases. Reported herein is a patient diagnosed of acute AFOP associated with primary Sjögren's syndrome. The patient's condition promptly improved after treatment with corticosteroid.


Subject(s)
Pneumonia/etiology , Sjogren's Syndrome/complications , Female , Glucocorticoids/therapeutic use , Humans , Methylprednisolone/therapeutic use , Middle Aged , Pneumonia/drug therapy , Pneumonia/pathology , Prednisone/therapeutic use , Sjogren's Syndrome/drug therapy
SELECTION OF CITATIONS
SEARCH DETAIL
...