Multifunction E-Skin Based on MXene-PA-Hydrogel for Human Behavior Monitoring.

Hydrogels have attracted significant attention in various fields, such as smart sensing, human-machine interaction, and biomedicines, due to their excellent flexibility and versatility. However, current hydrogel electronic skins are still limited in stretchability, and their sensing functionality is often single-purpose, making it difficult to meet the requirements of complex environments and multitasking. In this study, we developed an MXene nanoplatelet and phytic acid-coreinforced poly(vinyl alcohol) (PVA) composite, denoted as MXene-PA-PVA. The strong hydrogen bonds formed by the interaction of the different components and the enhancement of chain entanglement result in a significant improvement in the mechanical properties of the PVA/PA/MXene composite hydrogel. This improvement is reflected in an increase of 271.43% in the maximum tensile strain and 35.29% in the maximum fracture stress. Moreover, the composite hydrogel exhibits excellent adhesion, water retention, heat resistance, and conductivity properties. The PVA/PA composite material combined with MXene demonstrates great potential for use as multifunctional sensors for strain and temperature detection with a strain-sensing sensitivity of 3.23 and a resistance temperature coefficient of 8.67. By leveraging the multifunctional characteristics of this composite hydrogel, electronic skin can accurately monitor human behavior and physiological reactions. This advancement opens up new possibilities for flexible electronic devices and human-machine interactions in the future.

Novel self-healing and recyclable fire-retardant polyvinyl alcohol/borax hydrogel coatings for the fire safety of rigid polyurethane foam.

Rigid polyurethane foam (RPUF) has attracted great attention as an insulation material, but its inherent flammability restricts its practical application. Developing a sustainable fire-retardant strategy that can improve its fire safety is particularly desirable and challenging. Herein, novel fire-retardant hydrogel coatings based on polyvinyl alcohol (PVA) and borax are proposed and applied in RPUF, and the self-healing, recyclability and flame retardant properties of the coatings are investigated. The dynamic and reversible cross-linked networks based on the borate ester bonds and hydrogen bonds endow the hydrogels with excellent repairability, recyclability, and elasticity. Compared with a neat RUPF, the coated RPUF exhibited improved fire-retardant properties without the inherent advantages being influenced and can be reflected by the 8% increase in the limiting oxygen index (LOI), 20% reduction in total heat release (THR), and 25% decrease in total smoke production (TSP) with the coatings, along with a rapid self-quenching behavior. The novel hydrogel coatings provide a new strategy for the development of flame-retardant coatings, demonstrating the potential of the next generation of self-healing hydrogel coatings to reduce the fire risk of the RPUF.

Facile fabrication of a novel self-healing and flame-retardant hydrogel/MXene coating for wood.

To improve flame retardancy of wood, a novel high-water-retention and self-healing polyvinyl alcohol/phytic acid/MXene hydrogel coating was developed through facile one-pot heating and freeze-thaw cycle methods, and then painted on wood surface. The coating exhibit excellent self-healing property and significantly enhanced water-retention property (water content ≥ 90 wt%), due to the increased hydrogen bonds within the coating system with the presence of MXene nanosheets. Compared to pristine wood, the flame retardancy of coated wood is greatly improved, such as passed V0 rating in UL-94 test, increasing time to ignition (TTI, from 32 to 69 s), and decreased heat release rate and total heat release by 41.6% and 36.14%. The cooling effect and large thermal capacity of high-water-retention hydrogel, and physical barrier effects for flammable gas products, heat and oxygen by MXene nanosheets and the compact char layer formed during combustion play key roles in the flame retardancy enhancements of the wood. High thermal stability of MXene nanosheets is another beneficial factor. The detailed flame-retardant and self-healing mechanisms were proposed.

Ecosystem service value evaluation method in a complex ecological environment: A case study of Gansu Province, China.

The scientific assessment of regional ecosystem service value (ESV) is helpful in developing scientific ecological protection plans and compensation policies. However, an ESV evaluation method that can adapt to the complex and diverse characteristics of the ecological environment has not been established. This study takes Gansu Province in China as an example, fully considering the regional differences in ecosystem service function. Five correction indices for the value equivalent factor per unit area were constructed on a provincial scale, and a regional difference adjustment index for 11 categories of ecosystem services was constructed on a regional scale. In this way, a value evaluation model based on regional differences was established. The results show that in 2015, the total ESV reached 2,239.56 billion yuan in Gansu Province, with ESV gradually increasing from the northeast to the southwest, and the high-value areas of service function being located in Qilian and Longnan Mountains. The forest and grassland ecosystems contributed the most to the ESV. From the perspective of value composition, local climate regulation and biodiversity maintenance functions are the main service functions of Gansu Province. From 2000 to 2015, ESV increased by 3.43 billion yuan in the province. The value of forest and urban ecosystems continued to increase, whereas the value of cultivated land ecosystem continued to decrease. In terms of spatial characteristics of the service value change, the area that experienced value reduction gradually moved from the central part of Gansu Province to the surrounding areas. The evaluation method proposed in this paper provides a relatively comprehensive evaluation scheme for the spatiotemporal dynamic evaluation of ESV in complex ecological environments.

Sequence diversity and functional characterization of the 5'-regulatory region of human CYP2C19.

Cytochrome p4502C19 (CYP2C19) plays an important role in drug biotransformation and has been shown to be genetically polymorphic. While polymorphisms in the coding region that have large effects on activity are well described, until recently, a lack of knowledge of the promoter sequence has hindered efforts to study it. Genetic variants in the promoter region have not been described and factors that influence its gene expression via promotor regulation remain largely undefined. We have cloned and sequenced 1.8 kb of the human CYP2C19 promoter. This promoter contains a number of putative transcription factor sites, including HepG2-specific factor 1, glucocorticoid response element, estrogen receptor element, constitutive androstane receptor and peroxisome proliferator-activated receptor. Sequencing of DNA obtained from 67 individuals identified eight single nucleotide polymorphisms within this region. No sequence of a known human pregnane X receptor response element was found in this section of the CYP2C19 promoter, despite the known effect of rifampin on the expression of this gene. A plasmid containing the 1.8-kb CYP2C19 promoter coupled to a luciferase reporter gene has been constructed and demonstrated to be functional and sensitive to induction by omeprazole in HuH7 cells. Nested deletions of CYP2C19 promoter were generated and the ability of serial promoter deletion constructs to activate luciferase expression in the HepG2 cell line was analysed. These data make possible future studies to elucidate the molecular mechanisms by which CYP2C19 can be induced in clinical settings and the consequences of genetic variability in its promoter.

Clinical significance of the cytochrome P450 2C19 genetic polymorphism.

Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large differences in the pharmacokinetics of a number of clinically important drugs. On the basis of their ability to metabolise (S)-mephenytoin or other CYP2C19 substrates, individuals can be classified as extensive metabolisers (EMs) or poor metabolisers (PMs). Eight variant alleles (CYP2C19*2 to CYP2C19*8) that predict PMs have been identified. The distribution of EM and PM genotypes and phenotypes shows wide interethnic differences. Nongenetic factors such as enzyme inhibition and induction, old age and liver cirrhosis can also modulate CYP2C19 activity. In EMs, approximately 80% of doses of the proton pump inhibitors (PPIs) omeprazole, lansoprazole and pantoprazole seem to be cleared by CYP2C19, whereas CYP3A is more important in PMs. Five-fold higher exposure to these drugs is observed in PMs than in EMs of CYP2C19, and further increases occur during inhibition of CYP3A-catalysed alternative metabolic pathways in PMs. As a result, PMs of CYP2C19 experience more effective acid suppression and better healing of duodenal and gastric ulcers during treatment with omeprazole and lansoprazole compared with EMs. The pharmacoeconomic value of CYP2C19 genotyping remains unclear. Our calculations suggest that genotyping for CYP2C19 could save approximately 5000 US dollars for every 100 Asians tested, but none for Caucasian patients. Nevertheless, genotyping for the common alleles of CYP2C19 before initiating PPIs for the treatment of reflux disease and H. pylori infection is a cost effective tool to determine appropriate duration of treatment and dosage regimens. Altered CYP2C19 activity does not seem to increase the risk for adverse drug reactions/interactions of PPIs. Phenytoin plasma concentrations and toxicity have been shown to increase in patients taking inhibitors of CYP2C19 or who have variant alleles and, because of its narrow therapeutic range, genotyping of CYP2C19 in addition to CYP2C9 may be needed to optimise the dosage of phenytoin. Increased risk of toxicity of tricyclic antidepressants is likely in patients whose CYP2C19 and/or CYP2D6 activities are diminished. CYP2C19 is a major enzyme in proguanil activation to cycloguanil, but there are no clinical data that suggest that PMs of CYP2C19 are at a greater risk for failure of malaria prophylaxis or treatment. Diazepam clearance is clearly diminished in PMs or when inhibitors of CYP2C19 are coprescribed, but the clinical consequences are generally minimal. Finally, many studies have attempted to identify relationships between CYP2C19 genotype and phenotype and susceptibility to xenobiotic-induced disease, but none of these are compelling.