ABSTRACT
OBJECTIVE: To assess the quality of life of people living with HIV or AIDS (PLWHA) and to identify influencing factors. METHODS: During September to December 2010, by a convenience sampling, a questionnaire survey was undertaken in 310 PLWHA living in Beijing, which included the general questionnaires, SF-36 for assessing quality of life and Berger-HIV stigma scale. T test and multivariable linear regression model were used to analyze the results. RESULTS: For the subjects investigated, the age was (32.87±8.76) years old. Homosexual behavior was the main dissemination (84.52%, 262/310). The results of SF-36 questionnaire were: the summary score 66.75±15.70; physical function 93.00±9.49, role physical 66.53±40.26, bodily pain 73.88±22.63, general health 50.06±22.75, vitality 61.11±19.67, social function 69.50±24.24, role emotional 59.68±42.38, mental health 60.63±19.81. Except physical functioning, the scores of every scale were lower than general persons (P<0.05). Multivariable linear regression analysis showed that the stronger stigma, the lower the summary score (standardized coefficients (ß')=-0.38), role physical (ß'=-0.21), bodily pain (ß'=-0.13), general health (ß'=-0.33), vitality (ß'=-0.31), social function (ß'=-0.34), role emotional (ß'=-0.31), mental health (ß'=-0.47) (all P values<0.05). The higher expend on treating HIV, the lower the summary score (ß'=-0.17), physical function (ß'=-0.28), role physical (ß'=-0.15), bodily pain (ß'=-0.19), general health (ß'=-0.15), social function (ß'=-0.11), role emotional (ß'=-0.16) (all P values<0.05). Who having work got higher score in the summary score (ß'=0.13), physical function (ß'=0.13), role physical (ß'=0.12), bodily pain (ß'=0.12), vitality (ß'=0.13), social function (ß'=0.12), role emotional (ß'=0.12) than others (all P values<0.05). CONCLUSION: The quality of PLWHA's life was low. High stigma feeling, high expend on treating HIV, having a job were the main influencing factors of quality of life in PLWHA.
Subject(s)
Acquired Immunodeficiency Syndrome , HIV Infections , Quality of Life , Acquired Immunodeficiency Syndrome/epidemiology , Adolescent , Adult , Aged , China/epidemiology , Female , HIV Infections/epidemiology , Humans , Male , Middle Aged , Surveys and Questionnaires , Young AdultABSTRACT
OBJECTIVE: To investigate the subtype distribution and the prevalence of sequence characteristics of HIV-1 strains in Beijing residents during 2006 and to analyze the relationship between distribution of HIV-1 subtypes and transmission routines. METHODS: Blood samples from 32 new confirmed HIV-1 infected individuals from Beijing residents in 2006 and separated plasma specimens were collected. RNAs were extracted and the gag and env gene were amplified by RT-PCR and nest-PCR. PCR products were sequenced directly and phylogenetic analyses of gag and env gene were performed using the MEGA2 software. RESULTS: Among 32 HIV-1 plasma samples, 22 gag and 4 env gene fragments were amplified and analyzed. Five HIV-1 subtypes or circulating recombinant forms(CRFs) of HIV-1 including Thai B (2 strains), B (9 strains), C (2 strains), CRF07_BC (5 strains), CRF01 AE (4 strains) were identified being circulated in Beijing. The gene divergences of gag gene inside the subtypes were 6.6%, 4.3%, 6.8%, 4.9% and 3.0% in subtype B, Thai B, C, CRF01_AE and CRF07_BC respectively. Subtypes B were predominant in Beijing, accounted for 40.9% among 22 samples. CONCLUSION: Five HIV-1 subtypes were identified in Beijing and the surveillance of HIV-1 gene variation should be paid more attention to.