Irritable bowel syndrome in children: the placebo response rate and influencing factors a meta-analysis.

BACKGROUND: Irritable bowel syndrome is common in children and exhibits a high placebo response. This study was to explore the placebo response rate and its influencing factors in children with irritable bowel syndrome. METHODS: A systematic search was performed on Pubmed, Embase, MEDLINE, Cochrane Library, CNKI, Wanfang, and CBM from database inception to March 2022. Randomized controlled trials of irritable bowel syndrome in children were included in the study. The primary outcome was the placebo response rate of improvement. RESULTS: Thirteen studies were included, with 445 patients in the placebo group. The rate of improvement and abdominal pain disappearance were 28.2% (95% CI, 16.6-39.9%) and 5% (95% CI, 0-18.4%). The placebo response based on the abdominal pain score was 0.675 (95% CI, 0.203-1.147). The mode of administration (P < 0.01), dosing schedule (P < 0.01), and clinical outcome assessor (P = 0.04) have a significant impact on the magnitude of placebo effect. CONCLUSIONS: The placebo response rate for pediatric irritable bowel syndrome was 28.2%. In clinical trials, reducing dosing frequency, selecting appropriate dosage forms, and using patient-reported outcomes can help mitigate the placebo effect. IMPACT: This is the first meta-analysis to assess the placebo response rates for improvement and disappearance in children with IBS. The finding suggested that the mode of administration, dosing schedule, and clinical outcome assessor could potentially influence the magnitude of the placebo effect in children with IBS. This study would provide a basis for estimating sample size in clinical trial design with a placebo control.

[On-orbit response variation analysis of FY-3 MERSI reflective solar bands based on Dunhuang site calibration].

MERSI is the keystone payload of FengYun-3 and there have been two sensors operating on-orbit since 2008. The on-orbit response changes obviously at reflective solar bands (RSBs) and must be effectively monitored and corrected. However MERSI can not realize the RSBs onboard absolute radiometric calibration. This paper presents a new vicarious calibration (VC) method for RSBs based on in-situ BRDF model, and vector radiometric transfer model 6SV with gaseous absorption correction using MOTRAN. The results of synchronous VC experiments in 4 years show that the calibration uncertainties are within 5% except for band at the center of water vapor absorption, and 3% for most bands. Aqua MODIS was taken as the radiometric reference to evaluate the accuracy of this VC method. By comparison of the simulated radiation at top of atmosphere (TOA) with MODIS measurement, it was revealed that the average relative differences are within 3% for window bands with wavelengths less than 1 microm, and 5% for bands with wavelengths larger than 1 microm (except for band 7 at 2.1 microm). Besides, the synchronous nadir observation cross analysis shows the excellent agreement between re-calibrated MERSI TOA apparent reflectance and MODIS measurements. Based on the multi-year site calibration results, it was found that the calibration coefficients could be fitted with two-order polynomials, thus the daily calibration updates could be realized and the response variation between two calibration experiments could be corrected timely; there are large response changes at bands with wavelengths less than 0.6 microm, the degradation rate of the first year at band 8 (0.41 microm) is about 14%; the on-orbit response degradation is maximum at the beginning, the degradation rates slow down after one year in operation, and after two years the responses even increase at some band with wavelengths larger than 0.6 microm.