ABSTRACT
In this paper, we demonstrate an adaptive liquid lens with a tunable field of view (FOV). The proposed liquid lens consists of an actuator and a lens chamber, the annular sheet is just placed on the liquid-liquid (L-L) interface in order to change the curvature and steer the tilt angle of the interface. Different from the conventional FOV adjustable lens combined with a liquid lens and a liquid prism, the proposed lens requires only one L-L interface to achieve the focal length change and FOV deflection. Moreover, the proposed lens reduces aberrations while maintaining high resolution. The experiments show that the optical power range is -27 m-1 to 30 m-1. It can realize the FOV deflection while tuning the focal length, with an angular resolution of 37"05. The proposed lens can be applied to telescopic system and microscopic system.
ABSTRACT
Splicing factor Heterogeneous Nuclear Ribonucleoprotein A2/B1 (HNRNPA2B1 ) is associated with mouse lifespan and human longevity.It also plays a causal role in cancer development.However, whether it participates in cellular senescence, a biological process that contributes to individual aging and inhibits cancer, remains unknown.Here, we report that HNRNPA2B1 showed significantly increased expression in various cancer types while consistently decreased expression in multiple cellular senescence models.Knocking down HNRNPA2B1 in cancer cells leads to a series of senescence- associated phenotvpes.In line with its function as a splicing factor, HNRNPA2B1 downregulation causes alternative splicing changes in over one thousand genes, including those known to have a causal role in senescence.Our results also suggests that the E2F transcription factor 1 (E2F1 ) could regulate the expression of HNRNPA2BI, and E2F1-HNRNPA2B1 may be a new regulatory axis functioning in both cancer and cellular senescence, which might also have potential medical implications for cancer therapies.
