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Bull Exp Biol Med ; 159(1): 111-5, 2015 May.
Article in English | MEDLINE | ID: mdl-26028235

ABSTRACT

To study demyelination and remyelination processes and their response to different drugs, a protocol for modeling multiple sclerosis using the copper chelator cuprizone was developed. Magnetic resonance imaging confirmed the presence of demyelination lesions on week 4 of 0.6% cuprizone-containing diet. Immunohistochemical staining with polyclonal antibodies to glial fibrillary acidic protein (pAb GFAP) confirmed the increase in the number of reactive astrocytes on week 4 of diet and during remyelination (week 2 after diet). Analysis of neurophysiological functions in mice with cuprizone-induced demyelination revealed motor and behavioral deficits. This model can be used as a tool for preclinical studies of the efficiency of multiple sclerosis diagnostic and therapy.


Subject(s)
Cuprizone/pharmacology , Demyelinating Diseases/chemically induced , Multiple Sclerosis/chemically induced , Myelin Sheath/metabolism , Nerve Tissue Proteins/metabolism , Animals , Brain/diagnostic imaging , Disease Models, Animal , Female , Glial Fibrillary Acidic Protein , Magnetic Resonance Imaging , Male , Mice , Mice, Inbred C57BL , Multiple Sclerosis/therapy , Radiography
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