1.
Chem Rev
; 110(9): 5235-331, 2010 Sep 08.
Article
in English
| MEDLINE
| ID: mdl-20608735
Subject(s)
Acetates/chemistry , Acetates/chemical synthesis , Acylation , Aldehydes/chemistry , Alkylation , Biological Products/chemical synthesis , Biological Products/chemistry , Heterocyclic Compounds/chemistry , Imines/chemistry , Ketones/chemistry , Polymerization , Stereoisomerism , Sulfur/chemistry
2.
J Org Chem
; 74(2): 884-7, 2009 Jan 16.
Article
in English
| MEDLINE
| ID: mdl-19099419
ABSTRACT
Chiral ortho esters of alpha-isocyano acids were synthesized from commercially available Cbz-protected alpha-amino acids. These compounds are stable toward racemization in the Ugi 4CC in contrast to known esters of alpha-isocyano acids. Applying them in Ugi 4CC with subsequent deprotection gives access to dipeptides with preserved configuration at the C-terminal amino acid.
