ABSTRACT
Biorhythms of iron metabolism in healthy women and patients with iron deficiency were studied during lactation. Healthy nursing women were characterized by circadian variations in the concentrations of iron, alpha-tocopherol, and malonic dialdehyde in breast milk. Diurnal variations in iron concentration, antioxidant potential, and lipid peroxidation in breast milk depended on iron metabolism in nursing women. Iron deficiency was accompanied by a decrease in the concentrations of alpha-tocopherol and iron, increase in malonic dialdehyde content, and suppression of circadian variations in these parameters in breast milk.
Subject(s)
Anemia, Iron-Deficiency/metabolism , Circadian Rhythm , Iron/metabolism , Milk, Human/chemistry , Adult , Female , Humans , Iron/analysis , Lactation , Malondialdehyde/analysis , Tocopherols/analysisABSTRACT
We studied biological rhythms of immunological parameters and absorption and digestive activities of neutrophils and monocytes in women during the menstrual cycle. Circadian rhythms of phagocytosis were evaluated. The phagocytic system was characterized by highest activity during ovulation and early luteal phase of the menstrual cycle accompanied by physiological immunosuppression. It was shown that macrophages determine the spatial and temporal organization of specific and nonspecific resistance in women. We evaluated phases of the menstrual cycle optimal for studying rhythms of the immune system and phagocytosis.
Subject(s)
Menstrual Cycle/immunology , Monocytes/immunology , Neutrophils/physiology , Periodicity , Adult , Female , HumansABSTRACT
Biorhythms of absorption capacity of neutrophils and monocytes were studied in women with latent iron deficiency. We revealed disorders in circadian organization of the mononuclear phagocyte system and decreased reserve capacity of nonspecific organism's resistance against the background of tissue iron deficiency. Informative value of desynchronosis in circadian structure of the phagocyte absorption capacity as the early marker of prelatent iron deficiency was established.
Subject(s)
Anemia, Iron-Deficiency/immunology , Periodicity , Phagocytes/immunology , Adult , Female , Humans , Menstrual Cycle/immunologyABSTRACT
Time organization of erythropoiesis and iron metabolism was studied in women of reproductive age. The studies showed that a constant level of erythrocytes and hemoglobin in peripheral blood during the menstrual cycle is maintained due to different intensity of erythropoiesis and iron metabolism. Circadian rhythm of sideremia is characterized by the greatest amplitude of fluctuations during the early lutein phase of the cycle in all healthy women. The difference between serum iron concentrations in the morning and afternoon (8.00-14.00) and in the evening (21.00-24.00) is 4-8 mumol/liter. A lesser difference between the morning and evening concentration of the trace element during the early lutein phase indicates iron dysmetabolism and is prognostically unfavorable with regard to development of iron deficiency.