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Cytotoxic effect of low-density lipoproteins.

Nagornev, V A; Voskan'yants, A N; Vinogradov, A G; Zhdanova, O Yu; Denisenko, A D.

Bull Exp Biol Med ; 135(1): 93-5, 2003 Jan.

Article in English | MEDLINE | ID: mdl-12717524

ABSTRACT

The cytopathogenic effect of various modified lipoproteins on cultured peritoneal macrophages was studied in vitro. After minor peroxide modification lipoproteins induced apoptosis of macrophages. Immune complexes containing oxidized lipoproteins caused cell necrosis.

Subject(s)

Lipoproteins, LDL/immunology , Macrophages, Peritoneal/immunology , Animals , Antigen-Antibody Complex/immunology , Apoptosis , Autoantibodies/immunology , Cells, Cultured , Lipid Peroxidation , Lipoproteins, LDL/metabolism , Macrophages, Peritoneal/metabolism , Male , Mice

ABSTRACT

Subject(s)

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