ABSTRACT
For the prevention of intrauterine infection in pregnant women in the identification of herpes virus infection in the acute stage or the presence of chronic infectionin combination with a complicated obstetric and gynecological history (miscarriage, still birth, intrauterine infection in a child) is recommended to treats pecific immunoglobulins. The studies demonstrated the efficacy of such a therapeutic and prophylactic complex, as.confirmed by the improvement of children's condition at birth, reduced frequency disadaptation syndromes, clinical signs of intrauterine infection (pneumonia, etc.), neonatal mortality, a decrease at 41.7% intrauterine infection frequency by laboratory test.
Subject(s)
Cervix Uteri/drug effects , Cytomegalovirus Infections/prevention & control , Herpes Genitalis/prevention & control , Immunoglobulins/therapeutic use , Pregnancy Complications, Infectious/prevention & control , Abortion, Spontaneous/prevention & control , Adult , Cervix Uteri/immunology , Cervix Uteri/virology , Cytomegalovirus/drug effects , Cytomegalovirus/immunology , Cytomegalovirus/pathogenicity , Cytomegalovirus Infections/immunology , Cytomegalovirus Infections/virology , Female , Herpes Genitalis/immunology , Herpes Genitalis/virology , Herpesvirus 2, Human/drug effects , Herpesvirus 2, Human/immunology , Herpesvirus 2, Human/pathogenicity , Humans , Infant , Infant, Newborn , Injections, Intramuscular , Perinatal Death/prevention & control , Pregnancy , Pregnancy Complications, Infectious/immunology , Pregnancy Complications, Infectious/virology , StillbirthABSTRACT
217 postmortem protocols of autopsies have been analyzed to study percentage of hemorrhagic complications. The analyzes allowed to determine frequency and localization hemorrhages happened in children bourn by mothers suffering from diabetes mellitus. The most detected localizations of hemorrhages are follows: ependyma (38.8%), ventricles of brain (30.8%), parenchyma of brain (30.8%) as well as frequently have been observed pleura, epicardium and adrenal glands hemorrhages.
Subject(s)
Antioxidants/metabolism , Diabetes Mellitus/metabolism , Hemorrhage/metabolism , Lipid Peroxidation , Pregnancy in Diabetics/metabolism , Catalase/metabolism , Diabetes Mellitus/enzymology , Female , Glutathione/metabolism , Hemorrhage/enzymology , Hemorrhage/mortality , Humans , Infant Mortality , Infant, Newborn , Lipid Peroxides/metabolism , Pregnancy , Pregnancy in Diabetics/enzymology , Superoxide Dismutase/metabolismABSTRACT
Described in the paper are chief pathogenetic mechanisms of development of disturbances in the hemostasis system in neonates born to mothers presenting with extragenital pathologies. Marked clotting changes were noted together with those in the system of the erythron. Recordable in the above infants were also vascular permeability disorders, abnormalities of metabolism. These changes were especially manifest in those children presenting with diabetic fetopathy and in babies born to mothers with neurocirculatory asthenia. The results secured permitted the development of the system of curative-and-prophylactic measures to be instituted in the above infants.
Subject(s)
Hemostasis , Hemostatic Disorders/blood , Hemostatic Disorders/etiology , Pregnancy Complications , Blood Coagulation , Capillary Permeability , Disease Susceptibility , Erythrocytes/pathology , Factor XII/metabolism , Female , Hemostatic Disorders/pathology , Humans , Infant, Newborn , Neurocirculatory Asthenia/complications , Pregnancy , Pregnancy Complications, Cardiovascular , Pregnancy Complications, Hematologic , Pregnancy in DiabeticsABSTRACT
Overall, fifty newborn infants born to mothers with extragenital pathology (diabetes mellitus) were studied for the coagulative link of the homeostasis system as were 20 babies born to essentially healthy mothers. The studies were made by day 1 to 3 and 5 to 7 the babies' life. The conducted studies revealed signs of hypercoagulation presenting with activation of the external and internal route of hemostasis in those infants born to mothers with diabetes mellitus (DM). Toward the period of early neonatal adaptation shifts are still observable in the coagulating system at the expense of stimulation of the first phase of coagulation. The disclosed abnormalities in the coagulative link of the coagulating system in infants born to DM mothers pose a threat of development of thrombohaemorrhagic complications.
Subject(s)
Blood Coagulation , Hemorrhage/blood , Thrombosis/blood , Adult , Blood Coagulation Tests , Diabetes Mellitus/blood , Disease Susceptibility/blood , Female , Humans , Infant, NewbornABSTRACT
A study was made on the condition of lipid peroxidation and of the antioxident system of defence in 20 infants born to healthy mothers (control group), 12 babies born to mothers with diabetes mellitus, 15 infants born to mothers with neurocirculatory asthenia and 12 infants born to mothers with congenital heart diseases. In infants born to mothers with diabetes mellitus and cardiovascular pathology, the system of regulation was found to have gotten out of balance, the compensatory-and-adaptive reactions upset. Accumulation of peroxidic products and depletion of the antioxidant system of defence tended to be more readily seen in those babies born to mothers with diabetes mellitus. The results secured attest to the need for employment of drugs endowed with antioxidant activity.
