ABSTRACT
Results of a preclinical study of the anxiolytic activity and safety of original Racium phytomedicine are presented. The preparation possessed high anxiolytic activity, exhibits a wide range of therapeutic effects, produces no lethality in male and female rats and mice upon single intragastric and intraperitoneal introduction in doses up to 5 g/kg (VI class of toxicity according to OECD), induces no pathologic effects upon prolonged (120 days) administration in these rodents, and has no local irritant and/or allergen action.
Subject(s)
Anti-Anxiety Agents/therapeutic use , Anxiety/drug therapy , Melissa/chemistry , Mentha piperita/chemistry , Phytotherapy , Plant Extracts/therapeutic use , Valerian/chemistry , Animals , Anti-Anxiety Agents/administration & dosage , Anti-Anxiety Agents/chemistry , Anxiety/physiopathology , Anxiety/psychology , Chromatography, High Pressure Liquid , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Drug-Related Side Effects and Adverse Reactions , Female , Injections, Intraperitoneal , Intubation, Gastrointestinal , Lethal Dose 50 , Male , Mice , Plant Extracts/administration & dosage , Plant Extracts/chemistry , Rats , Sesquiterpenes/analysisABSTRACT
Circadian rhythms of horizontal and vertical motor activity and characteristic features of stress dysrhythmia caused by territorial conflict were assessed in ICR outbred mice with polar zoosocial status. The rhythms of diurnal motility of non-stressed dominant and submissive mice do not differ considerably. The territorial conflict causes desynchronosis in both high- and low-ranking animals, manifesting itself through the shift of the acrophase of motor activity and change in spectral parameters of a chronogram.
