[The proteolysis-ion theory of the pathogenesis of nephrolithiasis]. / Proteolizno-ionnaia teoriia patogeneza pochechnokamennoi bolezni.

A study was made of urinary proteolysis. This parameter turned to be decreased in patients with nephrolithiasis versus normal subjects. The authors developed an original proteoclastic-ion theory of nephrolithiasis pathogenesis, based on the two main risk factors triggering the disease: low levels of urinary proteolysis leading to the formation of a calculous matrix; the urine pH values optimal for the sedimentation of lithiasic salts. The combination of both risk factors was responsible for the development of calculous crisis and the formation of microlith. The decreased index of urinary proteolysis calculated with the formula offered could be regarded as a risk indication to the microlith formation. A possible elimination of the both risk factors was demonstrated. The technique of microlithiasis metaphylaxis was developed with regard to the major and minor risk factors and the possibility of their elimination. The values of urinary proteolysis were the criteria for a successful therapeutic response. With regard to the number of risk factors the risk of primary nephrolithiasis or lithiasis relapses could be predicted.

[Ambiguous polyuridylic acid translation by transport RNA from various eukaryotic substances]. / Neodnoznachnost' transliatsii poliuridilovoi kisloty transportnymi RNK iz razlichnykh éukarioticheskikh ob"ektov.

Various eucaryotic tRNAs were compared from the standpoint of their ability to misread poly-U in the tRNA-dependent cell-free system of wheat germs. The highest level of 14C-leucine incorporation into the product of translation is observed for tRNA from differentiated (lactating) mammary gland under conditions of the increased Mg2+ concentration. Possible reasons may be connected with different tRNALeu/tRNAPhe ratios in these tissues and with the appearance of specific isoacceptory tRNA4Leu in the total set of tRNA from the lactating gland.