1.
J Biomol Struct Dyn
; 15(1): 69-80, 1997 Aug.
Article
in English
| MEDLINE
| ID: mdl-9283981
ABSTRACT
An extensive computer simulation of nucleic acid bases and Watson-Crick base pairs in a water cluster and DMSO cluster is performed by the Monte Carlo method. It is demonstrated that the unfavorable energetics of pair formation in a water cluster is determined by the significant destabilizing contribution of solvent to the energy of complex formation. It is shown that the formation of coplanar base pairs in a DMSO cluster is favorable. The DMSO cluster stabilizes A-U and A-T base pairs and the insignificant destabilization of the G-C base pair by a DMSO cluster is much less than the stabilization which occurs due to the attraction between bases.
Subject(s)
Base Composition , Nucleic Acids/chemistry , Computer Simulation , Dimethyl Sulfoxide , Hydrogen Bonding , Monte Carlo Method , Nucleic Acid Conformation , Solubility , Thermodynamics , Water
2.
J Theor Biol
; 30(3): 559-71, 1971 Mar.
Article
in English
| MEDLINE
| ID: mdl-4325050