ABSTRACT
KIR2DL1*030 differs from KIR2DL1*00302 by a single non-synonymous mutation in exon 4.
Subject(s)
Alleles , Exons , Killer Cells, Natural/immunology , Polymorphism, Single Nucleotide , Receptors, KIR2DL1/genetics , Amino Acid Substitution , Asian People , Base Sequence , Cloning, Molecular , Codon/chemistry , Gene Expression , Genotype , Histocompatibility Testing , Humans , Killer Cells, Natural/cytology , Polymerase Chain Reaction , Primary Cell Culture , Receptors, KIR2DL1/immunology , Sequence Alignment , Sequence Analysis, DNAABSTRACT
KIR2DL1*00602 differs from KIR2DL1*00302 by a non-synonymous mutation in exon 7.
Subject(s)
Alleles , Exons , Polymorphism, Single Nucleotide , Receptors, KIR2DL1/genetics , Amino Acid Substitution , Asian People , Base Sequence , Cloning, Molecular , Codon/chemistry , Gene Expression , Genotype , Hematopoietic Stem Cell Transplantation , Histocompatibility Testing , Humans , Polymerase Chain Reaction , Receptors, KIR2DL1/immunology , Sequence Alignment , Sequence Analysis, DNA , Tissue DonorsABSTRACT
HLA-A*02:431 differs from the closest allele HLA-A*02:03:01 by a nonsynonymous mutation at nucleotide 317 in exon 2.
Subject(s)
Alleles , HLA-A2 Antigen/genetics , Asian People/ethnology , Asian People/genetics , China/ethnology , Humans , MaleABSTRACT
The novel KIR3DL1*079 allele differs from KIR3DL1*0150201 by a single mutation at CDS nt1119 G>T.
Subject(s)
Alleles , Polymorphism, Single Nucleotide , Receptors, KIR3DL1/genetics , Amino Acid Substitution , Base Sequence , China , Codon , Exons , Gene Expression , Genetic Testing , Humans , Molecular Sequence Data , Molecular Typing , Receptors, KIR3DL1/immunology , Sequence AlignmentABSTRACT
The novel KIR2DL2*013 allele differs from the closest allele KIR2DL2*00302 by two non-synonymous mutations.
Subject(s)
Alleles , Asian People/genetics , Ethnicity/genetics , Receptors, KIR2DL2/genetics , Base Sequence , China , Humans , Molecular Sequence Data , Sequence AlignmentABSTRACT
KIR2DL3*027 differs from the closest allele KIR2DL3*00101 by a nonsynonymous mutation in exon 7.
Subject(s)
Alleles , Exons , Mutation , Receptors, KIR2DL3/genetics , Asian People , Base Sequence , China , Humans , Molecular Sequence DataABSTRACT
KIR2DL3*026 differs from the closest allele KIR2DL3*00101 by a nonsynonymous mutation in exon 4.
Subject(s)
Alleles , Exons , Mutation , Receptors, KIR2DL3/genetics , Asian People , Base Sequence , China , Humans , Molecular Sequence DataABSTRACT
The novel KIR2DL3*031 allele differs from KIR2DL3*00101 by a synonymous mutation and a non-synonymous mutation.
Subject(s)
Alleles , Mutation , Receptors, KIR2DL3/genetics , Asian People/ethnology , HumansABSTRACT
The novel KIR2DL3*025 allele differs from the closest allele KIR2DL3*0010101 by a non-synonymous mutation at CDS nt280 C>A in exon 4.
Subject(s)
Alleles , Mutation , Receptors, KIR2DL3/genetics , Asian People/ethnology , Female , Humans , MaleABSTRACT
KIR2DL3*030 differs from the closest allele, KIR2DL3*00101, by a single missense mutation at CDS.
Subject(s)
Alleles , Mutation, Missense , Receptors, KIR2DL3/genetics , Asian People/ethnology , HumansABSTRACT
KIR2DL3*00110 differs from KIR2DL3*00101 by a single silent mutation at coding sequence (CDS) nt618 A>C in exon 5.
Subject(s)
Alleles , Mutation, Missense , Receptors, KIR2DL3/genetics , Asian People/ethnology , HumansABSTRACT
KIR2DL3*029 differs from the closest allele KIR2DL3*00101 by a single missense mutation at CDS nt505 C > A.
Subject(s)
Alleles , Mutation, Missense , Receptors, KIR2DL3/genetics , Asian People/ethnology , HumansABSTRACT
The novel HLA-DPB1*166:01 allele differs from the closest allele DPB1*152:01 by a single missense mutation at CDS nt 315G>A in exon 2.
Subject(s)
Alleles , Databases, Nucleic Acid , Exons , HLA-DRB1 Chains/genetics , Mutation, Missense , Base Sequence , DNA Mutational Analysis , Histocompatibility Testing , Humans , Molecular Sequence DataABSTRACT
AIM: To study the therapeutic effect of intraperitoneal hyperthermic double-distilled water and cis-diaminodichloro-platinum (DDP) perfusion for cancerous ascites and radical gastrectomy. METHODS: LACA mice were injected peritoneally with H22 cancer cells (2 × 10(7) tumor cells). Five days later, the mice received treatments with either intraperitoneal perfusion of 37 °C isotonic fluid (group I), or 43 °C simple hyperthermic double-distilled water (group II), isotonic fluid (group III), DDP (group IV) or a combination of the hyperthermic double-distilled water with DDP (group V). A clinical experiment with intraperitoneal hyperthermic double-distilled water perfusion with DDP was carried out from September 1991 through September 1993 with 32 advanced gastric cancer patients who had undergone radical gastrectomy. RESULTS: In comparison with the untreated control group of cancer cell-bearing LACA mice, the mice in all treatment groups showed near complete obliteration of cancer cells in the peritoneal cavity, markedly reduced ascites, prolonged survival times, and reduced growth of peritoneal cancerous nodes. In the clinical experiment, all 32 patients with advanced carcinoma had achieved satisfactory results at the 1-year follow-up, but had unsatisfactory results at the 2-year follow-up. CONCLUSION: The intraperitoneal hyperthermic double-distilled water perfusion with DDP inhibited the occurrence of ascites in LACA mice bearing cancer cells, and prolonged the lifetime of patients with gastric cancer who had undergone radical gastrectomy.
