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Tuneable redox-responsive albumin-hitchhiking drug delivery to tumours for cancer treatment.
Fu, Shiwei; Zheng, Ajay; Wang, Lukun; Chen, Jiuyan; Zhao, Bowen; Zhang, Xiao; McKenzie, Victoria A A; Yang, Zixin; Leblanc, Roger M; Prabhakar, Rajeev; Zhang, Fuwu.
J Mater Chem B ; 12(27): 6563-6569, 2024 Jul 10.
Article in English | MEDLINE | ID: mdl-38899918

ABSTRACT

This paper outlines a novel drug delivery system for highly cytotoxic mertansine (DM1) by conjugating to an albumin-binding Evans blue (EB) moiety through a tuneable responsive disulfide linker, providing valuable insights for the development of effective drug delivery systems toward cancer therapy.


Subject(s)
Antineoplastic Agents , Drug Delivery Systems , Oxidation-Reduction , Humans , Antineoplastic Agents/chemistry , Antineoplastic Agents/pharmacology , Animals , Albumins/chemistry , Maytansine/chemistry , Maytansine/pharmacology , Mice , Neoplasms/drug therapy , Drug Carriers/chemistry , Cell Proliferation/drug effects , Cell Survival/drug effects , Drug Screening Assays, Antitumor
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