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1.
Biosens Bioelectron ; 75: 48-54, 2016 Jan 15.
Article in English | MEDLINE | ID: mdl-26296242

ABSTRACT

A portable colorimetric determination system based on G-quadruplex DNAzyme integrated with a smartphone was developed to quantitatively detect formaldehyde (FA). The method is based on the oxidation of FA by H2O2, which prevents the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS)­H2O2 reaction catalyzed by G-quadruplex halves. With the addition of FA, the amount of the blue-green-colored free-radical cation (ABTS+) was reduced. The concentration of FA can be determined by monitoring this competitive reaction with a UV-vis spectrometer. Response surface methodology (RSM) and Box-Behnken design (BBD) were applied for optimization of the colorimetric assay. A smartphone-based colorimetric reader was also developed, which could display FA responses and report the concentration in real-time. The system could detect FA as low as 0.01 µM with a linear range of 1-600 µM. Taking advantages of smartphone and DNAzyme, the assay provides great potential for its practical application as a home testing or on-site analysis with high sensitivity and selectivity.


Subject(s)
Air/analysis , Biosensing Techniques , Formaldehyde/isolation & purification , Smartphone , Benzothiazoles/chemistry , Colorimetry , DNA, Catalytic/chemistry , Formaldehyde/analysis , Formaldehyde/chemistry , G-Quadruplexes , Hydrogen Peroxide/chemistry , Sulfonic Acids/chemistry
2.
Nanoscale ; 7(22): 10210-7, 2015 Jun 14.
Article in English | MEDLINE | ID: mdl-25990823

ABSTRACT

A prerequisite for exploiting most proposed applications for MoS2 is the availability of water-dispersible functionalized MoS2 nanosheets in large quantities. Here we report one-step synthesis and surface functionalization of MoS2 nanosheets by a facile ionic liquid assisted grinding method in the presence of chitosan. The selected ionic liquid with suitable surface energy could efficiently overcome the van der Waals force between the MoS2 layers. Meanwhile, chitosan molecules bind to the plane of MoS2 sheets non-covalently, which prevents the reassembling of exfoliated MoS2 sheets and facilitates the exfoliation progress. The obtained chitosan functionalized MoS2 nanosheets possess favorable stability and biocompatibility, which renders them as promising and biocompatible near-infrared agents for photothermal ablation of cancer. This contribution provides a facile way for the green, one-step and large-scale synthesis of advanced functional MoS2 materials.

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