Aggregation-induced electrochemiluminescence enhancement of Ag-MOG for amyloid ß 42 sensing.

This study aimed to introduce an immunosensor for measuring amyloid ß 42 (Aß42) levels by aggregation-induced enhanced electrochemiluminescence (ECL). Metal-organic gels (MOGs) are novel soft materials with advantages such as high gel stability, good light-emitting properties, and easy preparation. This study used silver nanoparticle metal-organic gel (Ag-MOG) as a substrate to connect Aß42-Ab2 and the cathodoluminescent probe. Potassium persulfate was used as a co-reactant that could emit a high ECL signal. CuS@Au had the benefits of a relatively large surface area with excellent carrier function; therefore, it was used as a substrate to load a large amount of Aß42-Ab1, significantly improving the immunosensor sensitivity. The ECL intensity of Aß42 was linear in the range of 0.01 pg/mL to 250 ng/mL with a detection limit of 2.2 fg/mL (S/N = 3) under optimized detection conditions. This ECL immunosensor has been successfully applied to detect Aß42 in human serum with the advantages of excellent stability and high selectivity. This method not only expands the potential applications of ECL immunosensors based on biological testing and clinical diagnosis but also provides a viable approach to basic clinical testing.

Fine-regulating ultramicropores in porous carbon via a self-sacrificial template route for high-performance supercapacitors.

Ultramicropores (size < 0.7 nm) are critically demanded to provide an efficient path for the penetration and transportation of electrolytes to achieve high-performance supercapacitors. Here, a self-sacrificial template approach is adopted, which introduces C8 alkyl chains with a kinetic diameter of 0.8-1 nm to occupy the cavity of a porous aromatic framework (PAF). During the heating process, the alkyl chains decompose from the dense architecture as the temperature increased from 500 to 600 °C, forming ∼1 nm micropores. The newly-obtained cavities provide sites for thermal-driven skeleton engineering (700-900 °C) to obtain ultramicropores. Based on the well-defined pore structure, the carbonized PAF solid revealed outstanding electrochemical performances, including high rate and long-term stability in a 6 M KOH electrolyte. Notably, the specific capacitance (294 F g-1) derived from the self-sacrificial template method exceeds the capability of all the other methods for the construction of ultramicropores including self-template strategy, carbonization of nanoparticles, and template-assisted strategy. The synthesis of ultramicroporous carbons via the self-sacrificial template route opens up a promising gate to adjust the porous structure for high-performance applications in supercapacitors.

Pyrene-Based Fluorescent Porous Organic Polymers for Recognition and Detection of Pesticides.

Eating vegetables with pesticide residues over a long period of time causes serious adverse effects on the human body, such as acute poisoning, chronic poisoning, and endocrine system interference. To achieve the goal of a healthy society, it is an urgent issue to find a simple and effective method to detect organic pesticides. In this work, two fluorescent porous organic polymers, LNU-45 and LNU-47 (abbreviation for Liaoning University), were prepared using π-conjugated dibromopyrene monomer and boronic acid compounds as building units through a Suzuki coupling reaction. Due to the large π-electron delocalization effect, the resulting polymers revealed enhanced fluorescence performance. Significantly, in sharp contrast with the planar π-conjugated polymer framework (LNU-47), the distorted conjugated structure (LNU-45) shows a higher specific surface area and provides a broad interface for analyte interaction, which is helpful to achieve rapid response and detection sensitivity. LNU-45 exhibits strong fluorescence emission at 469 nm after excitation at 365 nm in THF solution, providing strong evidence for its suitability as a luminescent chemosensor for organic pesticides. The fluorescence quenching coefficients of LNU-45 for trifluralin and dicloran were 5710 and 12,000 (LNU-47 sample by ca. 1.98 and 3.38 times), respectively. Therefore, LNU-45 serves as an effective "real-time" sensor for the detection of trifluralin and dicloran with high sensitivity and selectivity.