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Chem Commun (Camb)
; 57(72): 9084-9087, 2021 Sep 09.
Article
in English
| MEDLINE
| ID: mdl-34498613
ABSTRACT
A nickel-catalysed direct terminal monofluoromethlyation between alkyl tosylates and a low-cost, industrial raw material bromofluoromethane has been developed. This transformation has demonstrated high efficiency, mild conditions, and good functional-group compatibility. The key to success of this transformation lies in the ligand and mild base selection, ensuring the generation of various terminal monofluormethylation products.