Dose-response study of propofol combined with two different doses of esketamine for laryngeal mask airway insertion in women undergoing hysteroscopy.

Objective: To prospectively determine the median effective dose (ED50) of propofol for inhibiting a response to laryngeal mask airway (LMA) insertion when combined with different doses of esketamine in female patients. Methods: A total of 58 female patients (aged 20-60 years, ASAⅠ-Ⅱ) scheduled for elective hysteroscopy were enrolled and randomly divided into 2 groups, one of which was administered 0.2 mg/kg of esketamine (K1 group, n = 28) and the other 0.3 mg/kg of esketamine (K2 group, n = 30). The 2 groups received the corresponding doses of esketamine intravenously, followed by an intravenous injection of propofol (injection time was 30 s). The initial dose of propofol was 2 mg/kg, and the dose ratio of propofol in the adjacent patients was 0.9. If a positive reaction occurred due to LMA insertion, the dose ratio in the next patient was increased by 1 gradient; if not, the dose ratio was decreased by 1 gradient. The ED50, 95 % effective dose (ED95) and 95 % confidence interval (CI) of propofol for inhibiting a response to LMA insertion in the 2 esketamine groups were calculated using probit analysis. Results: The ED50 of propofol for inhibiting a response to LMA insertion in female patients was 1.95 mg/kg (95 % CI, 1.82-2.08 mg/kg) in the K1 group and 1.60 mg/kg (95 % CI, 1.18-1.83 mg/kg) in the K2 group. The ED95 of propofol for inhibiting a response to LMA insertion in female patients was 2.22 mg/kg (95 % CI, 2.09-2.86 mg/kg) in the K1 group and 2.15 mg/kg (95 % CI, 1.88-3.09 mg/kg) in the K2 group. Conclusion: Propofol combined with 0.3 mg/kg of esketamine has low ED50 and ED95 effective doses for inhibiting an LMA insertion response in female patients undergoing hysteroscopy and surgery. There were no significant adverse effects, but the additional dose of propofol and airway pressure were significantly higher than those in the group administered 0.2 mg/kg of esketamine. Based on the results, we recommend the combination of propofol with 0.2 mg/kg esketamine for optimal conditions during LMA insertion in women undergoing hysteroscopy.

Interspecies Phylogenetic Analysis of / 生物医学与环境科学（英文）

Objective@#This study aims to investigate the infection of @*Method@#Infection of the definitive human host and intermediate fish host by @*Results@#In 2016-2020, the average population infection rate of Hunan was 1.38%, while in Tongdao County the rate was up to 26.90%, and the highest fish infection rate was detected in Qiyang County (99.44% in the dorsal fin of @*Conclusion@#The systematically study of

Treatment of 60 patients with temporomandibular joint dysfunction by manipulative reduction of cervical vertebrae combined with Pi needle release / 中国骨伤

<p><b>OBJECTIVE</b>To evaluate the clinical effects of manipulative reduction of cervical vertebrae combined with Pi needle release for the treatment of temporomandibular joint dysfunction.</p><p><b>METHODS</b>From March 2012 to May 2017, 60 patients with temporomandibular joint dysfunction were treated by manipulative reduction of cervical vertebrae with Pi needle release, including 26 males and 34 females, ranging in age from 18 to 60 years old, with an average of 32.5 years old. The courses of the disease ranged from 1 week to 5 years, with a mean duration of 3 months. The patients were followed up before and after treatment by maximum active opening of temporomandibular joint, joint clicking and comparison of visual analogue scale (VAS) pain scores.</p><p><b>RESULTS</b>All 60 patients were followed up, and the duration ranged from 6 to 24 months, with an average of 12 months. The maximum active opening of temporomandibular joint increased from(1.99±0.47) cm before treatment to(3.17±0.19) cm. The joint clicking decreased from 100% before treatment to(27.33±13.51)% after treatment. The VAS score decreased from 4.73±0.67 before treatment to 1.80±0.53 after treatment.</p><p><b>CONCLUSIONS</b>Treatment of temporomandibular joint dysfunction by manipulative reduction of cervical vertebrae combined with Pi needle release has such advantages as easy operation, obvious curative effect, short course of treatment, which is an effective method for the treatment of temporomandibular joint dysfunction.</p>

Observation on pharmacological and clinical effects of Liangxue Huaban Granule in treatment of psoriasis / 中草药

Objective: To investigate the pharmacological and clinical effects of Liangxue Huaban Granule in the treatment of psoriasis. Methods: The models of vaginal epithelium cell mitosis and scaled tail epidermis in mice with estrogen cycle were used to observe the changes of mice after administration of Liangxue Huaban Granule so as to study its pharmacological effects. Meanwhile, 100 cases of patients with psoriasis were chosen and randomly divided into two groups, treatment group and control group, there were 50 cases in each group respectively. The patients in the treatment group were given Liangxue Huaban Granule orally, one bag each time and three times daily. The patients in the control group were given the decoction of Liangxue Huaban components orally, one dose with decocting water, half dose in the morning and evening, respectively. Both two groups had four months treatment, six months post visiting, in order to observe and compare the effects of the two groups and PASI grades which were statistically analyzed by SPSS 19.0. Results: Liangxue Huaban Granule could inhibit the mitosis of mouse vaginal epithelia and promote the formation of cuticular granular cells on scaled epidemis of mouse tail. In the clinical observation, the total effective rates in the treatment group and the control group are 88.00% and 90.00%, respectively. And there is no significant difference in lowering the severity index of psoriasis (PASI grades) and curative effect index between two groups. Conclusion: The Liangxue Huaban Granule can effectively improve and reverse the pathological model of psoriasis in mice. It has the definite clinical effects of curing psoriasis, And it is convenient to take and has stable quality. In addition, Liangxue Huaban Granule has certain clinical application value.

[Aluminum-tolerant characteristics of different Chamaecrista genotypes].

A hydroponic culture experiment was conducted to study the responses of 40 Chamaecrista varieties (lines) to 120 mg x L(-1) of Al3+, with the correlations between the relative tolerance values of various characters of different genotypes and the comprehensive evaluation coefficient compared. Among the characters of the genotypes, the relative plant height, relative root dry mass, relative shoot dry mass, and relative root activity could be selected as the important indices for screening the Al-tolerant genotype of Chamaecrista. In the test 40 Chamaecrista varieties (lines), the 86134R2, 2208, 3170, 316, 2211, and 2232 had stronger Al-tolerant capability, belonging to Al-tolerant genotype, whereas the 34721R1, 92985, and 3184 had weaker Al-tolerant capacity, belonging to Al-sensitive genotype.

Structural and photoluminescent studies of lanthanide complexes with tripodal triRNTB (N-substituted tris(benzimidazol-2-ylmethyl)amine): ligand substituent, anionic and secondary ligand effects.

Six N-substituted NTB ligands (NTB = (tris(benzimidazol-2-ylmethyl)amine), namely, triMeNTB (L1), triEtNTB (L2), triPrNTB (L3), triBuNTB (L4), triAlNTB (L5) and triBzNTB (L6), have been synthesized through replacing the H atoms on the NH groups by methyl, ethyl, (n)propyl, (n)butyl, allyl, and benzyl groups, respectively. Their corresponding Sm(3+), Eu(3+) and Tb(3+) complexes consisting of different anions or secondary ligands have been prepared and characterized by elemental analyses, IR spectra and single-crystal X-ray diffraction measurements. Three types of structural models have been obtained: (2) where two triTNTB ligands wrap around the Ln(3+) ion with anions (ClO(4)(-) and CF(3)SO(3)(-)) free of coordination, (3) where one triRNTB ligand holds the Ln(3+) ion with anions (Cl(-), NO(3)(-) and picrate) participating in coordination, and '(3) where one triNTB ligand and three secondary antipyrine ligands coordinate with the Ln(3+) ion. The Ln(3+) ions in (2) type complexes are 8-coordinating and display a slightly distorted cubic (LnN(8)) coordination geometry. The Ln(3+) ions in (3) and '(3) types complexes show two different coordination geometries: one is 7-coordinating ((3) with Cl(-) anion and '(3)), which can be described as a severely distorted cube short of one corner (LnN(4)Cl(3) or LnN(4)O(3)), and the other is 10-coordinating ((3) with NO(3)(-) and picrate anions) which can be regarded as a severely distorted cube with one corner substituted by a three-atom cap (LnN(4)O(6)). The photoluminescent study reveals that the complexes with different Ln(3+) ions show a general luminescent intensity tendency of Tb > Eu > Sm. The modification of the NTB molecule by altering R groups tunes the triplet states of the ligands and results in differentiable photophysical properties of the complexes. The anions or secondary ligand also have remarkable effects on the luminescent properties of the complexes.

Tris(1H-benzimidazol-2-ylmethyl)amine-solvent adducts.

The tris(1H-benzimidazol-2-ylmethyl)amine (ntb) molecule crystallizes in different solvent systems, resulting in two kinds of adduct, namely the monohydrate, C24H21N7.H2O or ntb.H2O, (I), and the acetonitrile-methanol-water (1/0.5/1.5) solvate, C24H21N7.C2H3N.0.5CH4O.1.5H2O or ntb.1.5H2O.0.5MeOH.MeCN, (II). In both cases, ntb adopts a tripodal mode to form hydrogen bonds with a solvent water molecule via two N-H...O and one O-H...N hydrogen bond. In (I), the ntb.H2O adduct is further assembled into a two-dimensional network by N-H...N and O-H...N hydrogen bonds, while in (II), a double-stranded one-dimensional chain structure is assembled via N-H...O and O-H...O hydrogen bonds, with the acetonitrile molecules located inside the cavities of the chain structure.