1.
International Journal of Pediatrics
; (6): 155-157, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-390612
ABSTRACT
Spleen tyrosine kinase(Syk) has been considered to be a signaling molecule of hematopoietic cells,which play an important role in lymphocyte maturation and activation of immune cells.Recent studies showed that Syk plays a crucial role in regulation of proliferation and migration in vascular smooth muscle cells.Prominent pathways include mitogen-activated protein kinases,phosphatidylinositol 3-kinases,Src and Rho-activated protein kinase.In this review,the role of Syk in those signal pathways is summarized.