[Persistence of Coxsackie A13 virus in the families of children ill with rheumocarditis]. / Persistentsiiia virusa Koksaki A13 v semiakh bol'nykh revmokarditom detei.

Virological and clinico-instrumental examinations were carried out three times during one year in 13 patients with rheumatic carditis and 34 of their relatives from 13 families. Besides, probands from 5 families had been examined 1-3 years before this study during treatment for rheumocarditis. Among 62 virus strains isolated from feces, blood, and nasopharyngeal washings in the family foci 40 were Coxsackie A13, 12: Coxsackie B1, B2, B5; 10 viruses were not identified. Coxsackie A13 virus was isolated from probands, siblings and parents in 11 out of 13 families. Virus-neutralizing antibodies to it were demonstrated in the great majority of probands and relatives, including those families where no virus had been isolated. Coxsackie A13 virus and antibodies to it were shown to persist throughout the observation period in most families.

[Experimental study of Coxsackie-streptococcal infection]. / Eksperimental'noe izuchenie koksaki-streptokokkovoi infektsii.

The pathological process due to Coxsackie A18 virus and hemolytic streptococcus infection was studied in adult white mice. Their synergistic effect was established as manifested by longer periods of virus detection in the blood and heart and the detection of the streptococcus in animals infected with an 8-fold lower dose. In cases of combined infection, signs of dystrophy, destruction and proliferation developed in the myocardium reaching the highest intensity when the virus and the microbe had been inoculated simultaneously.