ABSTRACT
The authors report the results of the treatment according to the programs BFM-ALL-90 and BFM-AML-83 and 87. A total of 110 children with acute lymphoblastic leukemia (ALL) and 35 with acute myeloblastic leukemia (AML) were treated with remission rate 94.5% and 74.5%, respectively. Under programmed treatment of ALL the recurrences occurred in 12.2% against 46% of the cases in nonprogrammed treatment. 2-year survival made up 75% and 47.3%, respectively. Among AML cases there were frequently prognostically unfavorable ones and patients with neuroleukemia this dictating the necessity of the treatment intensification and irradiation of the skull in AML. Improvement of adjuvant therapy is a must in advance of acute leukemia treatment.
Subject(s)
Leukemia, Myeloid, Acute/therapy , Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy , Child , Combined Modality Therapy , Critical Care , HumansABSTRACT
A rare disease with autosomal dominant inheritance was diagnosed in mother, her son and daughter. The condition was due to unstable hemoglobin Köln in 10% quantity. Clinical symptoms manifested most dramatically in a son, moderately in a daughter and slightly in a mother who had undergone splenectomy. All the hemolytic rises were provoked by antipyretics or, in occasional cases, by respiratory viral infections running with hyperthermia. To alleviate the symptoms, the son is scheduled for splenectomy.
Subject(s)
Hemoglobinopathies/diagnosis , Hemoglobins, Abnormal , Adult , Anemia, Hemolytic, Congenital Nonspherocytic/blood , Anemia, Hemolytic, Congenital Nonspherocytic/diagnosis , Anemia, Hemolytic, Congenital Nonspherocytic/genetics , Child , Female , Hemoglobinopathies/blood , Hemoglobinopathies/genetics , Hemoglobins, Abnormal/analysis , Humans , Male , RussiaSubject(s)
Anemia, Hemolytic, Congenital/etiology , Hemoglobins, Abnormal/analysis , Heterozygote , Adolescent , Amino Acids/blood , Anemia, Hemolytic, Congenital/blood , Anemia, Hemolytic, Congenital/therapy , Blood Transfusion , Chromatography, Ion Exchange , Electrophoresis , Erythrocyte Transfusion , Erythrocytes, Abnormal/pathology , Hemoglobins, Abnormal/isolation & purification , Humans , Male , SplenectomyABSTRACT
Roentgenoendovascular occlusion of the spleen has been suggested for the treatment of children with hereditary spherocytic hemolytic anemia as an alternative to splenectomy. The operation was conducted in 8 children aged from 1 to 11 years. Selective decontamination of the intestine was used for prevention of inflammatory complications. Occlusion of 60% of the splenic parenchyma results in a stable clinico-hematological effect and can be performed as a single stage. Young children could be operated on by this method.
