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1.
Sci Rep ; 12(1): 1541, 2022 01 27.
Article in English | MEDLINE | ID: mdl-35087142

ABSTRACT

In recent years, more and more deep learning frameworks are being applied to hyperspectral image classification tasks and have achieved great results. However, the existing network models have higher model complexity and require more time consumption. Traditional hyperspectral image classification methods tend to ignore the correlation between local spatial features. In this paper, a new hyperspectral image classification method is proposed, which combines two-dimensional Gabor filter with random patch convolution (GRPC) feature extraction to obtain spatial-spectral feature information. The method firstly performs dimensionality reduction through principal component analysis and linear discriminant analysis and extracts the edge texture and spatial information of the image using a Gabor filter for the reduced-dimensional image. Next, the extracted information is convolved with random patches to extract spectral features. Finally, the spatial features and multi-level spectral features are fused to classify the images using the Support Vector Machine classifier. In order to verify the performance of this method, experiments were conducted on three widely used datasets of Indian Pines, Pavia University and Kennedy Space Center. The overall classification accuracy reached 98.09%, 99.64% and 96.53%, which are all higher than other comparison methods. The experimental results reveal the superiority of the proposed method in classification accuracy.

2.
Preprint in English | bioRxiv | ID: ppbiorxiv-205211

ABSTRACT

The COVID-19 pandemic has taken a significant toll on people worldwide, and there are currently no specific antivirus drugs or vaccines. We report herein a therapeutic based on catalase, an antioxidant enzyme that can effectively breakdown hydrogen peroxide and minimize the downstream reactive oxygen species, which are excessively produced resulting from the infection and inflammatory process. Catalase assists to regulate production of cytokines, protect oxidative injury, and repress replication of SARS-CoV-2, as demonstrated in human leukocytes and alveolar epithelial cells, and rhesus macaques, without noticeable toxicity. Such a therapeutic can be readily manufactured at low cost as a potential treatment for COVID-19.

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