[Changes in the lipid content of the blood and erythrocyte membrane in patients with IHD under the influence of quantum therapy]. / Izmeneniia soderzhaniia lipidov krovi i éritrotsitarnoi membrany u bol'nykh IBS pod vliianiem kvantovoi terapii.

Laser therapy of coronary patients significantly diminished total cholesterol, low and very low density lipoproteins, triglycerides and atherogenic index persisting for 3-6 months. Primary changes in the structure of the lipid bilayer of a red cell membrane in response to laser radiation are considered to be an effect of the physical factor characterized by activation of lipid peroxidation, phospholipolysis, by growth of membrane cholesterol content (phase I). Mobilization of the adaptive mechanisms was accompanied by positive shifts in the structure pattern of a biomembrane with return to initial condition by the end of the therapy course (phase II). Further (III) phase of subcellular changes resultant from quantum effects lasted for 3 months and brought activation of the antioxidant system, reorganization of phospholipid membrane composition, an increase in osmotic resistance of red cells. This may produce a positive tendency in IHD.

[Membrane-active preparations as correctors of the nephrotoxicity of gentamicin]. / Membranoaktivnye preparaty kak korrektory nefrotoksichnosti gentamitsina.

At intracutaneous gentamicine injections in rats (dose 50 mg/kg) within 10 days the simultaneous application of anticalcium drugs makes nephrotoxic signs more pronounced; whereas antioxidants and essenciale make them less pronounced. Phospholipid complex, containing phosphatidylserin, sphingomyelin, and phosphatidylethanolamine does not exhibit a marked nephroprotective effect. The found character of changes in content of phosphoinozytols in urine indirectly confirms the role of disturbances of their metabolism in mechanism of aminoglycoside nephrotoxicity.

[Impairment of lipid metabolism in the liver and its correction after exposure to ethanol and antitubercular agents]. / Narusheniia lipidnogo obmena i ikh korrektsiia pri vozdeistvii na pechen' étanola i protivotuberkuleznykh sredstv.

Impairments in the lipid spectrum of rat liver tissue, developed as a result of long-term simultaneous effect of ethanol and antituberculosis drugs isoniazid ann rifampycin, were effectively corrected by means of phospholipid preparations as well as by legalone (sylimarine). Pyridoxine, tocopherol and ATP did not normalize the lipid metabolism under these conditions.

[Changes in blood phospholipid and sugar levels and hemocoagulation in long-term cooling]. / Izmenenie soderzhaniia fosfolipidov, sakhara krovi i gemokoaguliatsii pri dlitel'nom okhlazhdenii.

Overcooling of organism was accompanied by an initial increase of total phospholipids and sugar in blood serum with the subsequent gradual normalization.

[Alteration in the phospholipid spectrum of blood serum and the state of hemocoagulation in experimental loading with phospholipids]. / Izmenenie fosfolipidnogo spektra syvorotki krovi i sostoianie gemokoaguliatsii pri éksperimental'no sozdavaemom izbytke fosfolipidov.

Phosphatidyl serine, phosphatidyl choline and sphingomyelin were administered into rats separately and simultaneously (at natural ratios, up to the final concentration exceeding 2-fold the normal level in blood). The phospholipid spectrum was estimated in blood serum by means of thin-layer chromatography and the state of haemocoagulation was monitored by means of autocoagulogramms. Sphingomyelin, reducing the content of some physiologically active phospholipids, did not alter haemocoagulation. Administration of phosphatidyl choline, phosphatidyl serine and mixtures of phospholipids resulted in an increase in blood serum of phosphatidyl serine that was responsible for hypocoagulation effect. The accelerating effect of phosphatidyl choline on phosphatidyl serine and importance of the phosphatidyl choline-phosphatidyl serine complex in haemocoagulation is discussed.

[Circadian rhythm of liver phospholipids in the normal golden hamster and in opisthorchiasis]. / Sutochnyi ritm fosfolipidov pecheni zolotistogo khomiaka v norme i pri opistorkhoze.

Circadian rhythms of total phospholipids, individual fractions of phosphatide acid, cardiolipin, phosphatidyl ethanolamine, phosphatidylcholine, sphingomyelin, and lysolecithins in the liver of golden hamsters infected with opisthorchiasis (days 30 and 150 of invasion) and freed from helminths (day 92 after dehelminthization) are desynchronized in phase, amplitude and level.

[Circadian rhythm of changes in phospholipids and activity of non-specific phosphomonoesterases in rat liver]. / Izmenenie soderzhaniia fosfolipi dov i aktivnosti nespetsificheskikh fosfomonoesteraz v pecheni krys na protiazhanii sutok.

The circadian rhythm of the content of total and individual phospholipids and the activity of alkaline and acid phosphatases was revealed in the liver of 130 white rats by the biochemical and histochemical methods. The concentration of phospholipids and enzymatic activity rise during the day time (9 a.m. - 15 p.m.). The results obtained suggest a good agreement between the structural and metabolic features of the liver during its maximal functional activity.

[Effect of cooling on liver phospholipids]. / Vliianie okhlazhdeniia na fosfolipidy pecheni.

Phospholipid composition of rat liver tissue was distinctly altered in cooling. Single-term cooling caused a decrease in content of phosphatidic acids, cardiolipin, phosphatidyl diethanolamine, phosphatidyl serine but it increased the sphingomyelin level. Content of phosphatidyl choline and of lysolecithins was markedly decreased in short-term cooling. Prolonged cooling was accompanied by an increase in content of all the phospholipid fractions except of phosphatidyl choline. Appearance of monophosphoinositide in the phospholipid spectrum under all the conditions studied reflect the response of the organism to a stressing influence of cooling.