ABSTRACT
Nitrofurylacrylic acid sodium salt is a substance of moderate toxicity. Its LD50 for male rats after oral administration comprises 1220 mg/kg, for female rats--1400 mg/kg. The minimal toxic dose, in case of long-term administration comprises 14 mg/kg. At the level of doses from 0.04 to 4.0 mg/kg no mutagenic effect was detected. Oral and subcutaneous administration of minimal tolerance doses of the agent induced formation of malignant neoplasms developing, predominantly, from the epithelial tissue, with localization depending on the route of the agent administration. A conclusion has been made on impossibility of using this substance as a food additive.
Subject(s)
Acrylates/toxicity , Food Additives/toxicity , Lung Neoplasms/chemically induced , Nitrofurans/toxicity , Acrylates/administration & dosage , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Female , Food Additives/administration & dosage , In Vitro Techniques , Male , Maximum Allowable Concentration , Mice , Nitrofurans/administration & dosage , RatsSubject(s)
Chlortetracycline/administration & dosage , Liver/drug effects , Oxytetracycline/administration & dosage , Animals , Dose-Response Relationship, Drug , Drug Residues , Female , Fluorescent Antibody Technique , Food Contamination , Histocytochemistry , Liver/immunology , Liver/ultrastructure , Male , Microscopy, Electron , Rats , Time FactorsABSTRACT
Hygienic regulation of the use of the agents studied in animal experiments as food additives has been validated with respect to the dose level, regimen of addition and the period of waiting for slaughter. It is recommended that tylosin-phosphate should be included into the animals' ration as a food additive in a dose of 60 mg/kg for a short time (2-3 days), the period of waiting for slaughter being not less than 6-7 days. Addition of vitagrin has been recommended for young growing animals in a dose of 400-500 g/ton of feed. The dose of vitagrin should be reduced to 200-300 g/ton of feed one-two months before slaughter, with a 10-day period of waiting for slaughter.
Subject(s)
Animal Feed , Anti-Bacterial Agents/administration & dosage , Drug Therapy, Combination/administration & dosage , Food Additives/administration & dosage , Leucomycins/administration & dosage , Animal Husbandry , Animals , Anti-Bacterial Agents/pharmacokinetics , Drug Therapy, Combination/pharmacokinetics , Food Additives/pharmacokinetics , Leucomycins/pharmacokinetics , Poultry , Streptothricins , UkraineSubject(s)
Chemical and Drug Induced Liver Injury , Chlortetracycline/toxicity , Foodborne Diseases/etiology , Intestinal Diseases/chemically induced , Kidney Diseases/chemically induced , Streptomycin/toxicity , Adenosine Triphosphatases/antagonists & inhibitors , Animals , Electron Transport Complex IV/antagonists & inhibitors , Humans , Maximum Allowable Concentration , Mitochondria, Liver/enzymology , Succinate Dehydrogenase/antagonists & inhibitorsABSTRACT
Introduction of kormogrisein-10 and fradizin-10 into feeds of farm animals did not lead to accumulation in the animals' meat of grisin and tilozin residues or to an adverse effect of such meat on the body of experimental rats. In the course of oral administration of the preparations to the animals the authors determined the period of detectability of antibiotic residues in muscles and organs and the minimal toxic doses of the preparations.