ABSTRACT
Two-week cholesterol injections caused prolonged alterations of nuclear hepatocyte apparatus in all liver segments. These alterations resulted in the increased number of binuclear cells and hepatocytes containing large nuclei detected 1.5 month after the last cholesterol injection.
Subject(s)
Hypercholesterolemia/pathology , Liver/pathology , Animals , Cell Nucleus/ultrastructure , Cholesterol, Dietary/administration & dosage , Cholesterol, Dietary/adverse effects , Hypercholesterolemia/etiology , Liver/ultrastructure , Rabbits , Time FactorsABSTRACT
The liver in the white rats subjected to the effect of a low temperature for 80 days (23 h every day, 5-7 degrees C) has been studied by means of a complex of morphometric techniques. The investigation is also performed 35 days and 4 months after the exposure to cold has been stopped. In the animals decapitated immediately after the exposure to cold has been stopped, there is a certain decrease in the liver mass, in the size of hepatocytes, drop in the karyometric indices. The latter phenomenon is also observed in the liver of the animals 35 days after the exposure to cold has been stopped. In 4 months, the part of the binuclear hepatocytes and the nuclear size is greater than in the control.
Subject(s)
Cold Temperature , Liver/ultrastructure , Animals , Female , Organ Size , Rats , Time FactorsABSTRACT
White rats exposed to low temperature (5-7 degrees C) over 80 days showed a slow growth of the body weight and liver, lowering of liver glycogen and cholesterol content, increase in the relative weight of the thyroid gland and in the nuclei size of adrenal medulla, fall of blood 11-HOCS level, change in the mitotic phase ratio in the epithelium of the tongue and cornea, and an increase in the number of pathological mitoses in the cornea. A great number of changes did not appear fully reversible after the discontinuation of the exposure to low temperatures.
