ABSTRACT
Suppressor status of immunity in 34 patients with gastric cancer of the III-IV stages was studied before and after (15 days and 3 months) gastrectomy and gastrosplenectomy. The control group consisted of 42 healthy donors. It was shown that gastrectomy caused inhibition of the endogenous activity, but stimulated the function of the prostaglandin-producing suppressor cells while combined gastrosplenectomy induced inhibition of the function of both endogenous and prostaglandin-producing suppressor cells.
Subject(s)
Adenocarcinoma, Mucinous/immunology , Adenocarcinoma/immunology , Carcinoma/immunology , Gastrectomy , Splenectomy , Stomach Neoplasms/immunology , T-Lymphocytes, Regulatory/immunology , Adenocarcinoma/surgery , Adenocarcinoma, Mucinous/surgery , Carcinoma/surgery , Humans , Immunoglobulins/analysis , Leukocyte Count , Lymphoma, Non-Hodgkin/immunology , Lymphoma, Non-Hodgkin/surgery , Postoperative Period , Spleen/immunology , Stomach Neoplasms/surgerySubject(s)
Anemia, Hemolytic, Autoimmune/immunology , Autoimmune Diseases/immunology , Thrombocytopenia/immunology , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle AgedABSTRACT
The paper discusses data on combined T-activin and cytostatic drug treatment of 9 cases of extensive cancer of the kidney and 9 cases of disseminated malignant tumor of the testicle. An immunomodulating effect of T-activin was shown.
Subject(s)
Kidney Neoplasms/drug therapy , Peptides/therapeutic use , Testicular Neoplasms/drug therapy , Thymus Extracts/therapeutic use , Adjuvants, Immunologic/therapeutic use , Allopurinol/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bleomycin/administration & dosage , Cisplatin/administration & dosage , Fluorouracil/administration & dosage , Humans , Male , Vinblastine/administration & dosageSubject(s)
Arthritis, Juvenile/immunology , T-Lymphocytes , Adolescent , Child , Child, Preschool , Humans , Leukocyte CountABSTRACT
The levels of T-lymphocytes in untreated lymphoid malignancies in children and those after different schemes of chemoimmunotherapy were compared. The ratio of T-helper and T-suppressor cells changed in the course of treatment in correlation with the chemotherapeutic effect: the fraction of T mu cells practically did not change whereas the T gamma cell fraction decreased considerably in patients who revealed a good response to therapy. BCG treatment stimulated both populations but the response of T gamma cells was stronger. Transplantation of thymus was followed by an increase on T mu cells.
