ABSTRACT
The objective of our study was to define factors associated with atrial fibrillation (AF) in patients with hypertension (HTN) and preserved left ventricle systolic function. MATERIAL AND METHODS: Overall, 273 consecutive patients with HTN residing in urban area were included in the study. Patients were divided into 2 groups: the first - 60 patients with paroxysmal and persistent AF (33% men, age 62, 28 (10,02), the second - 213 patients without AF (33% men, age 59,37 (8,27). RESULTS: Stepwise logistic regression analysis demonstrated AF presence was associated with alcohol intake ≥ 7 drinks per week (OR 4,12; 95%CI: 1,04-16,35), low physical activity (OR 3,18; 95% CI: 1,32-7,68), higher hip circumference (OR 1,19; 95% CI: 1,08-1,31) and history of HTN (OR 1,10; 95% CI: 1,04-1,17). BMI was not associated with presence of AF (OR 0,75; 95% CI: 0,61-0,91). CONCLUSION: Thus in our urban population with hypertension, AF is associated with alcohol intake ≥ 7 drinks per week, low physical activity, increased hip circumference and history of hypertension.AF prevention should include modification of lifestyle.
Subject(s)
Atrial Fibrillation , Hypertension , Female , Heart Ventricles , Humans , Male , Middle Aged , Risk Factors , SystoleABSTRACT
Chronosensitivity to monosan was studied in acute clinicopharmacological tests at 7.00, 11.00, 15.00, 19.00 and 23.00 in 20 patients with ischemic heart disease, angina pectoris (class II-III). Arterial pressure, heart rate, hemodynamic parameters were measured before monosan intake, 1.5, 2, 3 and 21 hours after the intake of 20 mg. The findings indicate the existence of chronosensitivity of hemodynamics to monosan, circadian rhythm of sensitivity of the heart rate, systolic pressure, peripheral resistance. Acrophase of the sensitivity rhythm of the heart rate occurred at 13.42, systolic pressure at 21.54, mean arterial pressure at 00.41, total and peripheral resistance at 14.13, 15.18, respectively.
Subject(s)
Angina Pectoris/drug therapy , Hemodynamics/drug effects , Isosorbide Dinitrate/analogs & derivatives , Vasodilator Agents/therapeutic use , Angina Pectoris/physiopathology , Circadian Rhythm/physiology , Delayed-Action Preparations , Female , Follow-Up Studies , Humans , Isosorbide Dinitrate/therapeutic use , Male , Middle Aged , Time FactorsABSTRACT
AIM: To assess the efficacy of long-acting propranolol in elderly patients with essential hypertension (EH) and coronary disease (CD). MATERIALS AND METHODS: Sixteen patients (mean age 60 years) with EH and CD were examined using ECG and echoCG, chest rheoplethysmography, Holter ECG monitoring, and exercise test. Betacap was administered once a day in doses 40 or 80 mg at 10.00 or 13.00. RESULTS: The drug exerted an antianginal and hypotensive effect. Energy expenditures of the myocardium decreased and exercise tolerance improved; the drug was more effective in patients with the hyperkinetic circulation and if taken at 10.00. CONCLUSION: Betacap is an effective antianginal and hypotensive agent, recommended for therapy of elderly patients with EH and CD.
