Potential hypoglycaemic activity phenolic glycosides from Moringa oleifera seeds.

Moringa oleifera seed has remarkable curative effects on reducing blood pressure, blood sugar and enhancing human immunity. In this study, one novel phenolic glycoside (1) together with four known compounds 2-5 were isolated from the macroporous resin adsorption extract of M. oleifera seeds, and the compound 3 was reported for the first time from this plant. The structure of the new crystalline compound was determined on the basis of spectroscopic analyses including mass spectrometry, 1D and 2D NMR experiments. The hypoglycaemic activity of isolated compounds was investigated with HepG2 cell and STZ-induced mice. It was found that compound 1, 4 and 5 could promote the glucose consumption of insulin resistance cells and reduce blood glucose levels of STZ-induced mice. This study concludes that compound 1, 4 and 5 may be developed as new and safe hypoglycaemic drugs.

[Correlative analysis between CT pancreatic inflammatory infiltration degree and clinical disease severity of severe acute pancreatitis].

OBJECTIVE: To investigate the correlation between CT pancreatic inflammatory infiltration degree of severe acute pancreatitis (SAP) and the clinical disease severity, and to explore its prognostic value. METHODS: One hundred and nineteen (83) patients with confirmed diagnosis of SAP during 2008-2010 in West China Hospital of Sichuan University were retrospectively included into the study. Contrast-enhanced multi-detector-row CT (including dual source CT) scan was performed for all the patients. The abnormal imaging features, such as pancreatic and peri-pancreatic inflammatory changes, involvement of other organs and local complications, were observed and used to calculate several CT severity indexes. Also, the clinical data were collected and compared with CT severity indexes. RESULTS: The CT scores of SAP with local complications CCT severity index (CTSI) score, Balthazar CT score and the score of extra-pancreatic inflammation spread) were higher than those with smooth recovery (P < 0.01). The CT scores were positively correlated with the incidence of local complications of SAP. Among the CT indexes, the score of extra-pancreatic inflammation spread showed the larger area under the ROC curve (AUC = 0. 600) than CTSI score and Balthazar CT score. All CT severity indexes had relatively good correlation with APACHE II and Ranson scores. CONCLUSION: Among the CT severity indexes, the score of extra-pancreatic inflammation spread is superior to CTSI and Balthazar CT scores in predicting local complications of SAP, and has good correlation with APACHE II and Ranson scores.

[Correlation analysis of computed tomography imaging scoring to the presence of acute kidney injury in severe acute pancreatitis].

OBJECTIVE: To investigate the multi-detector-row spiral CT (MDCT) imaging findings of severe acute pancreatitis (SAP) complicated with acute kidney injury (AKI), and to evaluate the correlation of MDCT imaging scoring to the presence of AKI in SAP. METHODS: One hundred and nineteen patients with confirmed diagnosis of SAP during March 2008-December 2010 in our hospital were retrospectively included into the study. The imaging features including pancreatic size, areas and degrees of pancreatic necrosis, peripancreatic retroperitoneal and intraperitoneal inflammation and other organs involvement (liver, kidney, spleen, gastrointestinal tract, etc.) were observed, as well as related CT severity indexes such as Balthazar CT score, CT severity index (CTSI) and extra-pancreatic inflammation on CT (EPIC) score were calculated. At the mean time, the clinical data including serum creatinine, urine output and the eventual prognosis were collected and compared with CT indexes, which was used for statistical analysis. RESULTS: SAP with AKI patients were often associated with the high incidence of multiple organ dysfunction (MODS) (88.1%) and high mortality (47.6%). In SAP with AKI patients, the CT indexes were significantly higher than those of SAP without AKI patients. Among the CT indexes, EPIC score showed the larger area under the ROC curve (AUC = 0.903) than CTSI score (AUC = 0.721) and Balthazar CT score (AUC = 0.571). CONCLUSION: Among the CT indexes, EPIC score has a better prediction of AKI in SAP patients than CTSI and Balthazar CT scores.