ABSTRACT
Objective: The purpose of this study was to investigate the effectiveness of the Newman System model of care in the perioperative period for patients with endometrial cancer, to investigate the impact on psychological well-being, quality of life, and patient satisfaction. Methods: One hundred and eight patients with endometrial cancer who were treated in our hospital from January 2020 to January 2023 were selected as research subjects and were randomly divided into the control group (n=54) and the research group (n=54); the control group received conventional nursing care, and the research group added nursing care based on the conventional nursing care with Newman's systematic nursing care model including primary, secondary and tertiary care, comparing the psychological state score, quality of life score, coping style score, and satisfaction with nursing care of the two groups. Results: After the intervention, the anxiety self-assessment scale (SAS) and depression self-assessment scale (SDS) scores decreased in both groups, with the research group having lower scores than the control group (P < .05). After the intervention, all Oncology Quality of Life Core Questionnaire (QLQ-C30) scores increased in both groups, with the research group having higher scores than the control group (P < .05). After the intervention, avoidance and submission scores decreased in both groups, with the research group having lower scores than the control group (P < .05); coping scores increased in both groups, with the research group having higher scores than the control group (P < .05). Satisfaction with care was higher in the research group than in the control group (P < .05). Conclusion: The Newman's system model of care is effective in the perioperative period of endometrial cancer, helping to reduce patients' negative emotions, optimize coping, improve quality of life and nursing satisfaction, and has great value in clinical application and promotion.
ABSTRACT
Advancements in cell coculture systems with porous membranes have facilitated the simulation of human-like in vitro microenvironments for diverse biomedical applications. However, conventional Transwell membranes face limitations in low porosity (ca. 6%) and optical opacity due to their large thickness (ca. 10 µm). In this study, we demonstrated a one-step, large-scale fabrication of freestanding polymer ultrathin porous (PUP) membranes with thicknesses of hundreds of nanometers. PUP membranes were produced by using a gap-controlled bar-coating process combined with polymer blend phase separation. They are 20 times thinner than Transwell membranes, possessing 3-fold higher porosity and exhibiting high transparency. These membranes demonstrate outstanding molecular permeability and significantly reduce the cell-cell distance, thereby facilitating efficient signal exchange pathways between cells. This research enables the establishment of a cutting-edge in vitro cell coculture system, enhancing optical transparency, and streamlining the large-scale manufacturing of porous membranes.
Subject(s)
Membranes, Artificial , Polymers , Humans , Coculture Techniques , PorosityABSTRACT
Bacillus cereus spores are concerns for food spoilage and foodborne disease in food industry due to their high resistance to heat and various disinfectants. The aim of this study was to investigate the inactivation of B. cereus spores by slightly acidic electrolyzed water (SAEW) in comparison to sodium hypochlorite (NaClO) with same available chlorine content (ACC). In this study, the efficacy of SAEW with different concentrations of ACC (40, 60, 80, 100, and 120 mg/L) on the inactivation of B. cereus spores, and the effect of SAEW combined with mild heat treatment (60°C), was examined in pure culture suspensions. Heat resistance and pyridine-2,6-dicarboxylic acid (DPA) release of the spores were also determined. The results showed that the sporicidal effect of the SAEW was significantly higher compared with the NaClO with the same concentration of ACC. Furthermore, the inactivation efficacy was largely dependent on ACC and treatment time. Moreover, the sporicidal activity of the SAEW was significantly improved when combined with a mild heat treatment (60°C). The majority of the DPA was released from spores, and the spores exhibited less resistance to heat after SAEW treatment for 30 min. These findings indicate that SAEW could effectively inactivate B. cereus spores, making it a promising and environmentally friendly decontamination technology for application in the food industry.
