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Bioorg Med Chem Lett
; 24(3): 790-3, 2014 Feb 01.
Article
in English
| MEDLINE
| ID: mdl-24433860
ABSTRACT
Inhibition of the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway is one of the most intensively studied approaches to cancer therapy. Rational design led to the identification of novel 7-amino-5-methyl-1,6-naphthyridin-2(1H)-one derivatives as potent PI3K/mTOR dual inhibitors. Design, synthesis and structure activity relationship are reported.