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Nat Prod Res ; 28(16): 1219-24, 2014.
Article in English | MEDLINE | ID: mdl-24666327

ABSTRACT

Axinelline A, a new cyclooxygenase-2 (COX-2) inhibitor, was isolated from Streptomyces axinellae SCSIO02208. The structures of compounds 1-9 were determined by analysing the NMR and MS data. The absolute configuration of 1 was determined by using optical rotation and comparing with the reported data. Compound 1 exhibited COX-2 inhibitory activity, the IC50 value being 2.8 µM.


Subject(s)
Catechols/isolation & purification , Catechols/pharmacology , Cyclooxygenase 2 Inhibitors/isolation & purification , Cyclooxygenase 2 Inhibitors/pharmacology , Streptomyces/chemistry , Catechols/chemistry , Cyclooxygenase 2 , Cyclooxygenase 2 Inhibitors/chemistry , Molecular Structure , Nuclear Magnetic Resonance, Biomolecular
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