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Nat Prod Res
; 28(16): 1219-24, 2014.
Article
in English
| MEDLINE
| ID: mdl-24666327
ABSTRACT
Axinelline A, a new cyclooxygenase-2 (COX-2) inhibitor, was isolated from Streptomyces axinellae SCSIO02208. The structures of compounds 1-9 were determined by analysing the NMR and MS data. The absolute configuration of 1 was determined by using optical rotation and comparing with the reported data. Compound 1 exhibited COX-2 inhibitory activity, the IC50 value being 2.8 µM.