ABSTRACT
Through the hemodialysis machine and water treatment systems maintenance, the result of complications caused by dialysis can be eliminated. It also of extended the life of hemodialysis machines and improve the quality of dialysis.
Subject(s)
Humans , Equipment Failure , Equipment and Supplies , Reference Standards , Maintenance , Renal Dialysis , Water Supply , Reference StandardsABSTRACT
A series of mutual prodrugs derived from gabapentin, pregabalin, memantine, venlafaxine were synthesized and their pharmacological properties to treat neuropathic pain were investigated in a rat model of chronic sciatic nerve constriction injury (CCI). In vivo evaluation demonstrated that the mutual prodrugs 2002413A, 2002823A composed of two gabapentins, 2002414 composed of gabapentin and pregabalin were effective in reversal tactile allodynia in CCI rats. The prodrugs 2002413A, 2002414 had no significant influence on the rotarod activity. The result suggest that the prodrugs may be possible candidates for further development.
