Density Analysis of Adsorption Phase in the Thermodynamic Study of Shale Gas Adsorption.

Understanding the adsorption mechanism and precisely predicting the thermodynamic adsorption properties of methane at high pressure are crucial while very challenging for shale gas development. In this study, we demonstrated that the Langmuir adsorption model combining with different empirical methods to determine the adsorption phase density makes the calculated isothermal adsorption heat violate Henry's law at low pressure. For instance, the isothermal adsorption heat calculated by the Langmuir-Freundlich model contradicts Henry's law when the absolute adsorption quantity is zero. Given the current challenge in accurately calculating the adsorption phase density, it is necessary to impose constraints on the parameters of the adsorption model by adhering to Henry's law to maintain thermodynamic consistency. We found that the adsorption phase volume of methane molecules lies between the micropore volume and the total pore volume when shale adsorption reaches saturation. The adsorption mechanism involves not only filling micropores but also monolayer adsorption in meso-macro pores. The high-energy adsorption sites for methane are primarily concentrated in organic matter, while within these methane adsorption areas in shale, the high-energy adsorption sites for water are mainly located in kaolinite within clay minerals. The zero-pressure heat of adsorption is a temperature-independent thermodynamic index, yet it is influenced by the water content. It can therefore be selected as a quantitative measure to evaluate the impact of methane adsorption on water.

The influence of tactical formation on physical and technical performance across playing positions in the Chinese super league.

This study aimed to investigate the impact of tactical formations on the physical and technical performance of professional football players in the Chinese Super League (CSL). A sample of 800 games from the 2015-2021 CSL was analyzed, and players' physical (total distance covered, distance covered while ball in play, number of sprints, sprint distance, and high/middle/low-speed running) and technical (gain/loss of possession, ball retention percentage, challenges, challenge success percentage, passes, and pass success percentage) performance was assessed across six team formations: 3-5-2 (n = 137), 4-3-3 (n = 77), 4-2-3-1 (n = 391), 4-4-2 (n = 257), 3-4-3 (n = 41), and 4-1-4-1 (n = 107). Linear mixed models were used to assess variations in performance indicators across positions and formations. The results demonstrated that central defenders traveled significantly more total and low-speed running distances in the 3-5-2 formation than in the 4-2-3-1 formation (ES range: 0.33-0.34, p < 0.01). Fullbacks in the 3-5-2 formation demonstrated more high-speed running than did those in the 4-4-2 formation (ES = 0.27, p = 0.04). The central midfielders exhibited significantly more sprints and longer sprint distances in the 4-2-3-1 formation than in the 4-4-2 formation (ES range: 0.2-0.24, p < 0.01). Regarding technical performance, central defenders displayed significantly greater ball retention percentages, passes, and pass success rates in the 3-4-3 than in the 3-5-2 formations (ES range: 0.58-0.65, p < 0.01). Moreover, fullbacks and central midfielders executed markedly more passes with superior pass success rates in 4-back formations than in 3-5-2 formations (ES range: 0.2-0.53, p < 0.01). These findings can help coaches and academic staff understand the physical and technical requirements of various positions in various tactical formations, thus optimizing the training process.

Mapping the youth soccer: A bibliometrix analysis using R-tool.

In recent years, there has been an increase in the scientific production of youth soccer. However, a panoramic map of research on this subject does not exist. The aim of this study was to identify global research trends in youth soccer over time, among the main levels of analysis: sources, authors, documents, and keywords. The bibliometric software Biblioshiny was used to analyze 2606 articles in Web of Science (WoS) published between 2012 and 2021. The main conclusion is that US and UK scholars dominate the research; the topics of research are changing with the real needs, and research on the topic of performance has been of interest to scholars; talent identification and development, performance, injury prevention, and concussion are the studies of interest to scholars in this area. This finding, which offers a global picture of youth soccer research over time, can help future research in this or similar domains.

Hydrochemistry, Sources and Management of Fracturing Flowback Fluid in Tight Sandstone Gasfield in Sulige Gasfield (China).

Hydraulic fracturing technologies have been frequently utilized in the oil and gas industry as exploration and development efforts have progressed, resulting in a significant increase in the extraction of natural gas and petroleum from low-permeability reservoirs. However, hydraulic fracturing requires a large amount of freshwater, and the process results in the production of large volumes of flowback water along with natural gas. In this study, three tight sandstone gas wells were fractured in the Sulige gasfield (China), and a total of 103 flowback fluid samples were collected. The hydrochemical characteristics, water quality and sources of hydrochemical components in the flowback fluid were discussed. The results show that the flowback fluid is characterized by high salinity (Total dissolved solids (TDS) up to 38,268 mg/L, Cl- up to 24,000 mg/L), high concentrations of metal ions (e.g., Fe, Sr2+, Ba2+) and high chemical oxygen demand (COD). The flowback fluid is a complex mixture of fracturing fluid and formation water, and its composition is impacted by water-rock interactions that occur during hydraulic fracturing. The major contaminants include COD, Fe, Ba2+, Cl-, Mn and pH, which constitute a high risk of environmental pollution. Meanwhile, chemical elements such as K, Ba and Sr are unusually enriched in the flowback fluid, which has an excellent potential for recycle of chemical elements. The Sulige gasfield's flowback fluid recovery methods and treatment scenarios were discussed, taking into consideration the pollution and resource characteristics of the flowback fluid. Options for dealing with the flowback fluid include deep well reinjection, reuse for making up fracturing fluid, recycling of chemical elements and diverse reuse of flowback water. This research offers guidance for managing the fracturing flowback fluid in unconventional oil and gas fields.

Effects of Concurrent Strength and HIIT-Based Endurance Training on Physical Fitness in Trained Team Sports Players: A Systematic Review and Meta-Analysis.

BACKGROUND: Concurrent strength and HIIT-based endurance training (CT) has merit in time-saving in team sports. However, the effect of CT on physical fitness remained equivocal. This meta-analysis aimed to determine whether CT would produce an interference effect on the development of physical fitness when compared to strength training (ST) or HIIT-based endurance training (HET) alone in trained team sports players. METHODS: A total of 2478 studies from three databases were screened. 52 full texts were reviewed. Seven studies were finally included and then subgroups were used for quantitative analysis. RESULTS: Compared to ST alone, CT had a significant effect on the development of maximal lower-body strength in trained team sports players (MD 4.20 kg, 95% CI 0.71-7.68, p = 0.02, I2 = 20%), but there was no significant difference between the groups on training adaptation in lower-body power (SMD 0.08, 95% CI -0.23-0.39, p = 0.62, I2 = 26%). Furthermore, a sub-group analysis based on the internal organization order of CT revealed that there was no statistically significant subgroup effect between CT and ST alone in all parameters. CONCLUSIONS: Well-designed CT regimens did not interfere with the development of physical fitness of trained team sports players.

Population pharmacokinetics of voriconazole and initial dosage optimization in patients with talaromycosis.

The high variability and unpredictability of the plasma concentration of voriconazole (VRC) pose a major challenge for clinical administration. The aim of this study was to develop a population pharmacokinetics (PPK) model of VRC and identify the factors influencing VRC PPK in patients with talaromycosis. Medical records and VRC medication history of patients with talaromycosis who were treated with VRC as initial therapy were collected. A total of 233 blood samples from 69 patients were included in the study. A PPK model was developed using the nonlinear mixed-effects models (NONMEM). Monte Carlo simulation was applied to optimize the initial dosage regimens with a therapeutic range of 1.0-5.5 mg/L as the target plasma trough concentration. A one-compartment model with first-order absorption and elimination adequately described the data. The typical voriconazole clearance was 4.34 L/h, the volume of distribution was 97.4 L, the absorption rate constant was set at 1.1 h-1, and the bioavailability was 95.1%. Clearance was found to be significantly associated with C-reactive protein (CRP). CYP2C19 polymorphisms had no effect on voriconazole pharmacokinetic parameters. Monte Carlo simulation based on CRP levels showed that a loading dose of 250 mg/12 h and a maintenance dose of 100 mg/12 h are recommended for patients with CRP ≤ 96 mg/L, whereas a loading dose of 200 mg/12 h and a maintenance dose of 75 mg/12 h are recommended for patients with CRP > 96 mg/L. The average probability of target attainment of the optimal dosage regimen in CRP ≤ 96 mg/L and CRP > 96 mg/L groups were 61.3% and 13.6% higher than with empirical medication, and the proportion of Cmin > 5.5 mg/L decreased by 28.9%. In conclusion, the VRC PPK model for talaromycosis patients shows good robustness and predictive performance, which can provide a reference for the clinical individualization of VRC. Adjusting initial dosage regimens based on CRP may promote the rational use of VRC.

The evaluation of playing styles integrating with contextual variables in professional soccer.

Purpose: Playing styles play a key role in winning soccer matches, but the technical and physical styles of play between home and away match considering team quality in the Chinese Soccer Super League (CSL) remain unclear. The aim of this study was to explore the technical and physical styles of play between home and away matches integrating with team quality in the CSL. Materials and methods: The study sample consists of 480 performance records from 240 matches during the 2019 competitive season in the CSL. These match events were collected using a semi-automatic computerized video tracking system, Amisco Pro®. A k-means cluster analysis was used to evaluate team quality and then using principal component analysis (PCA) to identify the playing styles between home and away matches according to team quality. Differences between home and away matches in terms of playing styles were analyzed using a linear mixed model. Results: Our study found that PC1 presented a positive correlation with physical-related variables such as HIRD, HIRE, HSRD, and HSRE while PC2 was positively associated with the passing-related variables such as Pass, FPass, PassAcc, and FPAcc. Therefore, PC1 typically represents intense-play styles while PC2 represents possession-play styles at home and away matches, respectively. In addition, strong teams preferred to utilize intensity play whereas medium and weak teams utilized possession play whenever playing at home or away matches. Furthermore, the first five teams in the final overall ranking in the CSL presented a compensated technical-physical playing style whereas the last five teams showed inferior performance in terms of intensity and possession play. Conclusion: Intensity or possession play was associated with the final overall ranking in the CSL, and playing styles that combine these two factors could be more liable to win the competition. Our study provides a detailed explanation for the impact of playing styles on match performances whereby coaches can adjust and combine different playing styles for ultimate success.

Engineering of Src Homology 2 Domain Leading to Sulfotyrosine Recognition With a High Affinity by Integrating a Distinctive Selection Theme and Next-Generation Sequencing.

Tyrosine sulfation plays a vital role in various biochemical reactions. Although sulfated tyrosine (sTyr) has a similar structure to phosphotyrosine (pTyr), the number of available sTyr sites is significantly less than that of pTyr sites, mainly because of the lack of effective sTyr probes. A few sTyr binders were identified on the basis of structural similarity by engineering the pTyr-binding pocket of an Src Homology 2 (SH2) domain through phage selections against sTyr peptides. Nevertheless, they still interact with pTyr peptides with comparable affinity. This study aims to identify sTyr superbinders using the SH2 domain as a template. We created a distinctive phage selection scheme that separately covered selections against sTyr and pTyr peptides, followed by next-generation sequencing (NGS). After selections, phage pools showed strong enzyme-linked immunosorbent assay (ELISA) signal intensities for both modified peptides, indicating that the variants evolved with a high affinity for these peptides, which causes difficulty in identifying sTyr-specific binders. In contrast, NGS data from selected pools showed significant differences, suggesting the enrichment of sTyr-specific variants during selections. Accordingly, we obtained the sTyr features based on NGS data analysis and prioritized a few potential sTyr binders. The variant SH2-4 showed a stronger affinity for sTyr than pTyr and was superior to previous sTyr binders as measured by the Biolayer Interferometry assay. In summary, we described the strategy of integrating NGS data mining with a novel selection scheme to identify sTyr superbinders.

Groundwater Pollution Source Identification and Apportionment Using PMF and PCA-APCS-MLR Receptor Models in Tongchuan City, China.

Potential sources of groundwater pollution in Tongchuan City, China, were qualitatively identified based on 14 key water quality indicators of 59 groundwater samples, and the contribution of each source to groundwater quality was quantitatively evaluated. Groundwater pollution sources were analyzed using PMF and PCA-APCS-MLR models, and their applicability in groundwater pollution assessment in Tongchuan City was tested. Results indicate that both models identified four sources of groundwater contamination. Natural evolution was the main cause of groundwater pollution in the study area, followed by the coal industry, agriculture, and urbanization. Although the spatial distribution of pollution sources in the two models differed, the urbanized area to the east of the study area was more severely affected by sewage discharge, the west was more obviously affected by the coal industry, and the north was mainly polluted by agriculture. Both of the fitting results of the two models are good, but R2 values obtained by the PMF model (0.4440-0.9991) were generally higher than those obtained by the PCA-APCS-MLR model (0.5180-0.9530), indicating that PMF model results were more accurate than the PCA-APCS-MLR model.

Long-Term Trend Analysis of Playing Styles in the Chinese Soccer Super League.

The aim of this study was to identify playing styles adopted by teams in the Chinese Soccer Super League (CSL) and to investigate their evolution across a 6-season period. Data were collected from 1,429 CSL matches from 2012 to 2017 seasons using the Amisco system. Seventeen technical performance-related indicators and eleven physical performance-related indicators were included in the factor analysis (PCA: principal components analysis) in order to group them into performance factors (styles of play). Seven factors were obtained (eigenvalues greater than 1) and explained 74.44% of the total variance. Multivariate analyses of covariance (MANCOVA) were used to check differences among seven styles of play (team's ranking was used as a covariate) during the six seasons under study. The main findings showed that Factor 1 (high intensity play) and factor 3 (offensive actions) of CSL soccer increased substantially along the seasons. Coaches and sports scientists should take into consideration these performance trends when preparing training and controlling for matches.

Influence of Match Congestion on Performances in the National Basketball Association.

The ability to recover from official match-play across a single and multiple matches is often considered a key factor in subsequent performance for modern professional basketball. The aims of this study were to: (i) explore the differences in match performances between different match congestion cycles (i.e., matches separated by zero, one, or two or greater days of rest); and (ii) identify the key performance indicators (KPIs) discriminating between winning and losing during different match congestion cycles. The current study indicated that scoring close to (i.e., within the paint) (ES = 0.08) or very far away (i.e., Three-point, ES = 0.05) was significantly greater for winning matches separated by 1- and 2-days of rest compared to consecutive matches (i.e., 0 rest days between matches). Additionally, shooting efficiency (P < 0.001), and attaining Defensive Rebounds (P < 0.001) and Steals (P < 0.001), were significant offensive and defensive KPIs that differentiated winning and losing teams. Similarly, opponent quality and match pace were important situational variables that affected match outcome during different match congestion cycles. While match location had an impact on winning following 1- and 2-days of rest, it had no impact for back-to-back matches (i.e., 0 days between matches). The current results will support coaches' offensive, defensive and recovery strategies during various match congestion cycles for a greater probability of winning NBA matches.

Voriconazole Versus Amphotericin B as Induction Therapy for Talaromycosis in HIV/AIDS Patients: A Retrospective Study.

Disseminated talaromycosis caused by Talaromyces marneffei is a life-threatening opportunistic infection. Although amphotericin B deoxycholate (dAmB) remains the first-line induction treatment, voriconazole can also be used. However, no clinical trials have compared dAmB and voriconazole in the administration of talaromycosis. We retrospectively evaluated the efficacy and safety of voriconazole or dAmB as induction therapy for talaromycosis in HIV-infected patients. We enrolled HIV-infected patients with a confirmed Talaromyces marneffei infection who received intravenous dAmB (0.6 to 0.7 mg/kg daily for 2 weeks) or voriconazole (6 mg/kg every 12 h on day 1 and 4 mg/kg every 12 h afterward) as induction therapy, followed by oral itraconazole as consolidation and maintenance therapy. Drug efficacy was evaluated based on response rate. Drug safety was evaluated based on the occurrence of adverse events. In total, 58 patients who received voriconazole and 82 who received dAmB were enrolled from two hospitals. The voriconazole and dAmB treatment groups had similar response rates at the primary and follow-up efficacy evaluations. However, the durations of induction antifungal therapy and hospital stay were shorter for patients in the voriconazole group than in the dAmB group. Few adverse reactions occurred in either the voriconazole or dAmB group. Our retrospective study indicated that voriconazole is an effective and safe induction antifungal drug for HIV-associated disseminated talaromycosis. The duration of induction treatment with voriconazole was shorter, indicating its potential as a better choice in clinical practice. The duration of voriconazole induction therapy is 11 to 13 days.

Long-term influence of technical, physical performance indicators and situational variables on match outcome in male professional Chinese soccer.

This study aimed to determine whether the role of technical, physical performance indicators and situational variables in determining match outcome has varied from a long-term analysis (seasons 2012 to 2017) of the Chinese Soccer Super League (CSL). The sample included 1,429 matches where 17 technical performance-related indicators, 11 physical performance-related indicators and two situational variables (match location and quality of opposition) were analysed. Three binary logistic regression models (inclusion of different variables) were used to measure the level of association between factors and match outcome over the six seasons studied. Results of models 1 and 2 revealed that shots on target, possession, total distance in ball possession, total distance out of ball possession, and match location exerted a decreased influence on winning the matches from 2012 to 2014 seasons. However, these indicators play a more important role in winning matches from 2014 to 2017 seasons. Additionally, the quality of opposition has a continuously increased negative effect on the match outcome. In model 3, more variables, such as high-speed distance, high-speed out of ball possession, had a meaningful influence on winning the match. These results provide valuable information about performance indicators and situational variables on winning the matches from a long-term approach.

An Activatable Triplet Sensitizer Based on Triplet Electron Transfer and Its Application for Triplet-Triplet Annihilation Upconversion.

Activatable triplet photosensitization refers to a photosentization process which can be turned on/off easily by external stimulus. Activatable triplet photosensitizations are normally achieved by interfering with the singlet excited state before the intersystem cross process (ISC), i.e., the formation process of triplet states of sensitizer. To achieve novel activatable triplet photosensitization, a disulfide-bridged porphyrin zinc(II) dyad (ZnPor-S-S-ZnPor) is prepared. Although fast ISC can be conducted in this dyad, an extremely low efficiency is obtained when employing this dyad as a triplet donor in triplet-triplet annihilation upconversion (TTA-UC) for sensitizing perylene. This is because of the presence of electron transfer from the triplet state of the porphyrin zinc(II) unit to the disulfide bond, which quickly quenches the triplet state of the porphyrin zinc(II) unit. This electron transfer process can be stopped by the cleavage of the disulfide bond in the presence of thiol, and TTA-UC efficiency can be enhanced significantly. Our result demonstrates for the first time that the disulfide bond can act as not only an easy cleavage linker but also a triplet electron acceptor. Furthermore, quenching the triplet states of sensitizer by triplet electron transfer provides an alternative protocol for designing activatable triplet sensitizers except controlling the singlet excited state before the ISC process.

The evolution of physical and technical performance parameters in the Chinese Soccer Super League.

Performance analysis in soccer has attained greater importance for coaching staff in order to gather and manage useful information (i.e., physical, technical, and tactical) of their teams during consecutive seasons. Accordingly, we examined the evolution of physical and technical performance parameters in the Chinese Soccer Super League (CSL). Data were collected from 1,429 CSL matches from the 2012 season to the 2017 season using the Amisco Pro (Amisco, Nice, France) system. Fourteen technical performance-related indicators and 11 physical performance-related indicators were analysed using a mixed linear model for repeated measures. Significant main effects of season were followed up using the Bonferroni correction (multiple comparisons). Although there were some irregularities, performance variables generally showed significant upward trends across the six seasons (p<0.05), resulting in significant increases from the 2012 season to the 2017 season in the total sprint distance (2,069.7±509.3 m vs. 2,272±493.6 m; p<0.001; effect size [ES]: 0.40), number of sprints (100.1±22.8 vs. 104.8±20.8, p<0.001; ES: 0.22), high-speed distance (2568.4±503.5 m vs. 2823.1±479.2 m; (p<0.001; ES: 0.52), and high-speed effort (187.5±36.1 to 204.7±33.7; p<0.001; ES: 0.49). Furthermore, there were ~23% more crosses (p<0.001; ES: 0.45), ~12% more shots on target (p<0.001; ES: 0.22), and ~11% more opponent penalty area entries (p<0.001; ES: 0.20) during the 2017 season than in the 2012 season. Coaches and sports scientists should be mindful of this evolution when preparing training sessions and recruiting new players, and even when predicting future trends in the Chinese Soccer Super League.

Match Performance of Soccer Teams in the Chinese Super League-Effects of Situational and Environmental Factors.

To investigate the effects of situational factors (match location, strength of team and opponent) and environmental factors (relative air humidity, temperature and air quality index) on the technical and physical match performance of Chinese Soccer Super League teams (CSL). The generalized mixed modelling was employed to determine the effects by using the data of all 240 matches in the season 2015 collected by Amisco Pro®. Increase in the rank difference would increase the number of goal-scoring related, passing and organizing related actions to a small-to-moderate extent (Effect size [ES]: 0.37-0.99). Match location had small positive effects on goal-scoring related, passing and organizing related variables (ES: 0.27-0.51), while a small negative effect on yellow card (ES = -0.35). Increment in relative air humidity and air quality index would only bring trivial or small effects on all the technical performance (ES: -0.06-0.23). Increase in humidity would decrease the physical performance at a small magnitude (ES: -0.55--0.38). Teams achieved the highest number in the physical performance-related parameters at the temperature between 11.6 and 15.1 °C. In the CSL, situational variables had major effects on the technical performance but trivial effects on the physical performance, on the contrary, environmental factors affected mainly the physical performance but had only trivial or small impact on the technical performance.