The Correlation between Atrial Fibrillation and Prognosis and Hemorrhagic Transformation.

OBJECTIVE: Atrial fibrillation (AF) is the recognized risk factor for hemorrhagic transformation (HT) in thrombolysis patients with acute ischemic stroke (AIS). But the impact of AF on prognosis is still controversial. In our study, we aimed to assess the relationship between AF and HT and prognosis. METHODS: We assessed 184 patients diagnosed with AIS and received thrombolysis from January 2016 to October 2017. Based on the imaging results during hospitalization, the patients were divided into HT and non-HT groups in which the HT was containing 40 patients. According to the modified Rankin Scale (mRS), we divided the patients into favorable prognosis (mRS score of 0-2) and the poor (mRS score >2) after 3 and 6 months of follow-up. Our analysis included demographics, onset to treatment time, initial blood pressure, baseline National Institutes of Health Stroke Scale (NIHSS) score, HT, anticoagulants, AF, smoking, and other past history. RESULTS: At baseline, there was a significant difference (p < 0.05) between the HT and non-HT groups in the level of age, hyperlipidemia, AF, NIHSS, and the application of anticoagulants. After 3 and 6 months of follow-up, we found that only NIHSS (OR3 month 1.421, 95% CI 1.280-1.578, p < 0.001, and OR6 month 1.326, 95% CI 1.217-1.445, p < 0.001) was associated with prognosis instead of AF, HT, and anticoagulants. Meanwhile, patients with AF tended to be older, higher NIHSS score and less hyperlipidemia (p < 0.05). CONCLUSION: The present study indicated that there is no significant correlation between AF and prognosis, although there is some indeed related with HT. That was, the prognosis with AF had a similar response trend compared with the non-AF.

Analytical and simulation studies of driven diffusive system with asymmetric heterogeneous interactions.

Totally asymmetric simple exclusion process (namely, TASEP) is one of the most vital driven diffusive systems, which depicts stochastic dynamics of self-driven particles unidirectional updating along one-dimensional discrete lattices controlled by hard-core exclusions. Different with pre-existing results, driven diffusive system composed by multiple TASEPs with asymmetric heterogeneous interactions under two-dimensional periodic boundaries is investigated. By using detailed balance principle, particle configurations are extensively studied to obtain universal laws of characteristic order parameters of such stochastic dynamic system. By performing analytical analyses and Monte-Carlo simulations, local densities are found to be monotone increase with global density and spatially homogeneous to site locations. Oppositely, local currents are found to be non-monotonically increasing against global density and proportional to forward rate. Additionally, by calculating different cases of topologies, changing transition rates are found to have greater effects on particle configurations in adjacent subsystems. By intuitively comparing with pre-existing results, the improvement of our work also shows that introducing and considering totally heterogeneous interactions can improve the total current in such multiple TASEPs and optimize the overall transport of such driven-diffusive system. Our research will be helpful to understand microscopic dynamics and non-equilibrium dynamical behaviors of interacting particle systems.

[Advances in studies on bear bile powder].

In this paper, a detailed analysis was made on relevant literatures about bear bile powder in terms of chemical component, pharmacological effect and clinical efficacy, indicating bear bile powder's significant pharmacological effects and clinical application in treating various diseases. Due to the complex composition, bear bile powder is relatively toxic. Therefore, efforts shall be made to study bear bile powder's pharmacological effects, clinical application, chemical composition and toxic side-effects, with the aim to provide a scientific basis for widespread reasonable clinical application of bear bile powder.

[Studies and reports of Chinese cut crude drug's dosage in clinical prescription of traditional Chinese medicine (section of gynecology)].

OBJECTIVE: Study the actual dosage of clinical prescription in gynecology of traditional Chinese medicine (TCM), and offer the consummate data for formulating the dosage standard of Chinese cut crude drug. METHOD: We made use of the methods of stratified sampling and random sampling to investigate 41,226 broth prescriptions of gynecology of TCM in 21 various hospitals, 18 provinces, and constructed the database, then applied Weka KDD software to analyze. RESULT: We identified the frequency and clinical dosage intervals of 300 drugs, and the practical dosage of 155 drugs which dose has difference between in the actuality and in the pharmacopoeia. Most of drugs dosage centralized the three intervals: (3-6], (9-12], (12-15], and the concrete dosage were 9, 10, 12, 15 g, etc. CONCLUSION: The dosages in the pharmacopoeia are not coincided with the practical dosages in gynecology, and demand to revise. This paper will offer the consummate data for formulating the new dosage standard.

[Studies and reports of Chinese cut crude drug's dosage in clinical prescription of (section of medical department)].

OBJECTIVE: Study the actual dosage of clinical prescription in medical department of traditional Chinese medicine (TCM), and offer the consummate data for formulating the dosage standard of Chinese cut crude drug. METHOD: We made use of the methods of stratified sampling and random sampling to investigate 269 882 broth prescriptions of Medical Department of TCM in 21 various hospitals, 18 provinces, and constructed the database, then applied Weka KDD software to analyze. RESULT: We identified the frequency and clinical dosage intervals of 300 drugs, and the practical dosage of 155 drugs which dose has difference between in the actuality and in the pharmacopoeia. Most of drug's dosage centralized the four intervals: (3-6], (9-12], (12-15], (18-21], and the concrete dosage were 3, 6, 10, 12, 15, 20 g, etc. CONCLUSION: The dosages in the pharmacopoeia are not coincided with the practical dosages in internal medicine, and demand to revise. This paper will offer the consummate data for formulating the new dosage standard.

[Studies and reports of Chinese cut crude drugs dosage in clinical prescription of traditional Chinese medicine (section of pediatrics)].

OBJECTIVE: Study the actual dosage of clinical prescription in pediatrics of traditional Chinese medicine (TCM), and offer the consummate data for formulating the dosage standard of Chinese cut crude drug. METHOD: We made use of the methods of stratified sampling and random sampling to investigate 38 736 broth prescriptions of pediatrics of TCM in 21 various hospitals, 18 provinces, and constructed the database, then applied Weka KDD software to analyze. RESULT: We identified the frequency and clinical dosage intervals of 300 drugs, and the practical dosage of 155 drugs. Most of drug's dosage centralized the four intervals: (3-6], (6-9], (9-12], (12-15], and the concrete dosage were 6, 9, 10, 12, 15 g, etc. CONCLUSION: The dosages in the pharmacopoeia are not coincided with the practical dosages in pediatrics, and demand to revise. This paper will offer the consummate data for formulating the new dosage standard.

[Studies and reports of Chinese cut crude drugs dosage in clinical prescription of traditional Chinese medicine (section of surgery)].

OBJECTIVE: Study the actual dosage of clinical prescription in surgery of traditional Chinese medicine (TCM), and offer the consummate data for formulating the dosage standard of Chinese cut crude drug. METHOD: We made use of the methods of stratified sampling and random sampling to investigate 84,759 broth prescriptions of surgery of TCM in 21 various hospitals, 18 provinces, and constructed the database, then applied Weka KDD software to analyze. RESULT: We identified the frequency and clinical dosage intervals of 300 drugs, and the practical dosage of 155 drugs which dose has difference between in the actuality and in the pharmacopoeia. Most of drug's dosage centralized the four intervals: (3-6], (9-12], (12-15], (18-21], and the concrete dosage were 3, 6, 10, 12, 15, 20 g, etc. CONCLUSION: The dosages in the pharmacopoeia are not coincided with the practical dosages in surgery, and demand to revise. This paper will offer the consummate data for formulating the new dosage standard.

[Illumination of pharmacoeconomics on Chinese herbal medicine inject].

This text emphasizes the present condition of the production and usage to Chinese herbal medicine inject, from the research angle of view of the pharmacoeconomics. Inquiry into the Chinese herbal medicine injects of the funds throw and throw in a funds and resources, the output of clinical health result and output a circumstance with social welfare, explicit the Chinese herbal medicine injected to take up a great deal of medicine health resources, but output not optimistic. Put forward the important meaning of pharmacoeconomics evaluation to Chinese herbal medicine inject that appears on market behind and carry on the main contents of the pharmacoeconomics evaluation thus.

[Safety issues of traditional Chinese medical preparations containing arsenic substances: review starting from Niuhuang Jiedu Pian (Wan)].

By comprehensively reviewing the origin and history of Niuhuang Jiedu Wan and its "derivatives", we studied the clinical records of realgar, investigated its clinical usage, dosage, efficacy, and toxicity in the literatures. We pinpointed the factors that might be associated with safety problems of Niuhuang Jiedu Pian (Wan) and other traditional Chinese medicine (TCM) preparations containing arsenic substances. In this article we also put forward suggestions for strengthening the surveillance and administration of similar TCM preparations.