ABSTRACT
Since this article has been suspected of research misconduct and the corresponding authors did not respond to our request to prove originality of data and figures, "Long noncoding RNA DLX6-AS1 functions as a competing endogenous RNA for miR-577 to promote malignant development of colorectal cancer, by F.-R. Zhou, Z.-P. Pan, F. Shen, L.-Q. Huang, J.-H. Cui, K. Cai, X.-L. Guo, published in Eur Rev Med Pharmacol Sci 2019; 23 (9): 3742-3748-DOI: 10.26355/eurrev_201905_17800-PMID: 31115000" has been withdrawn. The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/17800.
ABSTRACT
OBJECTIVE: Recent researches have proved that long noncoding RNAs (lncRNAs) play essential roles in tumorigenesis. The aim of this study was to investigate the exact role of lncRNA DLX6-AS1 in the development of colorectal cancer (CRC), and to explore the possible mechanism. PATIENTS AND METHODS: DLX6-AS1 expression in CRC tissues was detected by Real Time-quantitative Polymerase Chain Reaction (RT-qPCR). Function assays were conducted to detect the effect of DLX6-AS1 on the proliferation and metastasis of CRC in vitro. Furthermore, luciferase reporter gene assay and RNA immunoprecipitation assay (RIP) were used to explore the underlying mechanism of DLX6-AS1. RESULTS: DLX6-AS1 expression in CRC samples was significantly higher than that of adjacent tissues. Loss of DLX6-AS1 markedly inhibited the proliferation, migration, and invasion of CRC cells. Furthermore, luciferase reporter gene assay and RIP assay showed that DLX6-AS1 acted as a competing endogenous RNA via sponging miR-577 in CRC. CONCLUSIONS: DLX6-AS1 could promote the proliferation, migration, and invasion of CRC by sponging miR-577, which might offer a potential therapeutic target for CRC.
ABSTRACT
By textral research of Chinese materia medica, commodity investigation and identification of crude drugs, it has been made clear that in the Chinese market presently the main species of Rhizoma Drynariae is Drynaria fortunei. The assay of naringin content has been set with HPLC. The average rate of recovery is 99.5%, RSD 1.9%.
Subject(s)
Drugs, Chinese Herbal/chemistry , Flavanones , Flavonoids/analysis , Plants, Medicinal/anatomy & histology , Chromatography, High Pressure Liquid , Plants, Medicinal/chemistry , Quality Control , Species SpecificityABSTRACT
An investigation was made on the shape, properties, tissue features, TLC identification and panaxoside content of the Panax quinquefolium introduced and cultured in China. The results showed that its quality was basically similar to that of the imported Panax quinquefolium.
