ABSTRACT
BACKGROUND Coronary artery bypass grafting (CABG) is a common procedure to circumvent the obstruction of coronary arteries when stents are unsuitable. CABG is a very traumatic surgery that requires redirecting blood flow to an external pump. Thus, this procedure has many risks during and after surgery, and minimizing these risks would greatly benefit the patients. MATERIAL AND METHODS We selected 126 patients with coronary artery syndrome and who were unsuitable for stent percutaneous coronary intervention. The observation group received minimally invasive direct coronary artery bypass (MIDCAB), while the control group was treated with off-pump CABG. RESULTS Blood markers and echocardiography before and after treatment improved equally in both groups. Neither group exhibited obvious adverse reactions, or liver and kidney function damage. However, surgical bleeding and postoperative observation days were significantly reduced in the MIDCAB group. Death and cardiac shock at the end of follow-up were significantly lower in the MIDCAB group. CONCLUSIONS Overall, the clinical benefits of MIDCAB and OP-CABG were similar, but MIDCAB significantly reduced postoperative hospital stay and intraoperative blood transfusion, and improved clinical prognosis.
Subject(s)
Coronary Artery Bypass, Off-Pump/methods , Minimally Invasive Surgical Procedures/methods , Adult , Aged , Aged, 80 and over , Biomarkers/blood , Case-Control Studies , Electrocardiography , Female , Follow-Up Studies , Humans , Male , Middle Aged , PrognosisABSTRACT
OBJECTIVE: To investigate the changes in tumor necrosis factor alpha (TNF-α) serum levels after cardiopulmonary bypass (CPB) in children with congenital heart disease (CHD), followed by a meta-analysis to analyze the clinical value of TNF-α in CPB. METHODS: Our cohort study enrolled 67 CHD children, assigned into off-pump group (n=32) and CPB group (n=35). The TNF-α serum levels in two groups were detected by ELISA before the operation (T1), at the end of the operation (0 hour, T2), and after 24 hours of the operation (T3). For meta-analysis, literature search was conducted to identify published case-control articles about the changes of TNF-α serum levels with CPB of CHD. RESULTS: The TNF-α levels in CPB group were lower than that in the off-pump group at T3 (P=.006). TNF-α level at T3 was significantly lower than that at T1 and T2 (all P<.05). Meta-analysis results further confirmed that the TNF-α levels of CHD children were dramatically decreased at T3 as compared to that at T1 and T2 (both P<.001). CONCLUSION: The TNF-α serum levels showed a transient and dramatic decline after 24 hours of CPB, and it may act as an important biological indicator for monitoring the efficacy of CPB in CHD children.
Subject(s)
Cardiopulmonary Bypass , Heart Defects, Congenital , Tumor Necrosis Factor-alpha/blood , Adolescent , Child , Child, Preschool , China/epidemiology , Cohort Studies , Female , Heart Defects, Congenital/blood , Heart Defects, Congenital/epidemiology , Heart Defects, Congenital/surgery , Humans , MaleABSTRACT
OBJECTIVE: To establish ecologically new modes of cultivating Coptis chinensis in woods and co-cultivating it with maize. METHODS: Based on the experience obtained from plot comparative test and production test, we used application-oriented research methods, and established new Coptis chinensis cultivation techniques that protect the natural environment. RESULTS: Coptis chinensis was harvested 6 years after cultivation. Yield of Coptis chinensis cultivated in forest (69.5 kg per 0.067 hm2) was higher with 3.7% than that in controls which cultivated under shed (67 kg). Yield of Coptis chinensis co-cultivated together with maize (168.4 kg per 0.067 hm2) was lower with 15.8% than that in controls which cultivated under shed (200 kg). CONCLUSION: The new cultivation modes of Coptis chinensis is an ecologically new technique that assures the good growth of medicinal plants, cereals, forest and animal husbandry.
