ABSTRACT
BACKGROUND: The most effective way to prevent hepatitis B virus (HBV) infection is vaccination. Synthesized data on vaccination coverage in adults against hepatitis B in China are scarce. We aimed to estimate the hepatitis B vaccination rate in adults in China. METHODS: We searched PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, WanFang, and Sinomed databases for observational studies published between 1 January 2011 and 1 October 2021. Data were extracted using a standardized form to estimate the pooled vaccination coverage rate and 95% confidence intervals (CI) based on inclusion and exclusion criteria. Subgroup analysis was employed to explore heterogeneity. This study is registered in PROSPERO, CRD42021293175. RESULTS: We identified 5128 records, of which 21 articles that included 34,6571 adults. The pooled coverage rate and 95% confidence intervals were 26.27% and 22.73-29.82%, respectively. The pooled coverage rates were 22.06% (95% CI: 15.35-28.78%), 33.81% (95% CI: 28.77-38.85%) and 23.50% (95% CI: 17.37-29.64%) in eastern China, central China and western China, respectively. Furthermore, males had a pooled hepatitis B vaccination coverage rate of 23.47% (95% CI: 15.61-31.33%), whereas, in females, the coverage rate was 26.60% (95% CI: 18.73-34.47%). The pooled hepatitis B vaccination coverage rate in the age group younger than 40 years was 36.93% (95% CI: 28.35-45.50%), while in the ≥40-year-old group, the pooled hepatitis B vaccination coverage rate was 17.09% (95% CI: 10.18-24.00%). The pooled hepatitis B vaccination coverage rate in urban areas (40.29%, 95% CI: 20.91-59.67%) was higher than in rural areas (16.54%, 95% CI: 7.80-25.29%). The average weighted, pooled hepatitis B vaccination coverage rate was 26.53% (20.25-32.81%) in 2011-2015 and 26.12% (22.04-30.20%) in 2016-2021. CONCLUSIONS: This systematic review provides the hepatitis B vaccination coverage rate of adults in China (26.27%). The low prevalence of vaccine-mediated immunity among adults in China underscores the urgent need for targeted immunization strategies for vulnerable Chinese adults to ensure progress toward the target of eliminating hepatitis B by 2030.
ABSTRACT
OBJECTIVE: The purpose of the study was to understand the epidemiological tendency and distribution of the disease across Qinghai province, so as to serve for the development of a scientific system for prevention and treatment. METHODS: Multi-stage lamination stochastic group sampling was applied in the study, with 6 counties randomly selected. The total sample size was 19 201 while the study was conducted in the format of indoor visit. For residents younger than 18 years of age, a questionnaire was distributed to them to obtain related basic information. While for those older than 18, an in-depth survey was conducted. In addition to the measurement of height, weight, blood pressure, 10% of the samples underwent a testing on blood sugar. A database was then developed via Epi Data 3.02 and all the data was processed and classified via Foxpro and SPSS 13.0 software. RESULTS: The overall morbidity rate was 67.76%, with females significantly higher than males. The morbidity rate was fixed at 65.85% after weighted by region. The morbidity rate increased significantly with age. The top 5 diseases identified would include those from digestive system (28.74%), heart cranial vascular (27.27%), rheumatism and bone joint (19.97%), respiratory system (12.46%), biography reproductive system (8.64%) and urinary system (7.39%). Data from by-region analysis showed that the morbidity rate was the highest in pastoral area (70.17%), followed by villages (66.32%) and cities (61.86%), while the kinds of top diseases in those regions were also different. Data from unhealthy lifestyle showed that 22.16% of the provincial population smoked cigarettes, 17.16% drank alcohol, and the rate of obesity was 3.41%. CONCLUSION: Significant differences in morbidity rates among different regions and different genders were found while the prevalence rates of disease significantly increased along with age.
