General recommendation for assessment and management on the risk of glucocorticoid-induced osteonecrosis in patients with COVID-19.

BACKGROUND/OBJECTIVE: Coronavirus disease 2019 (COVID-19) is a disaster in human medical history and glucocorticoids remain the most promising therapy. Osteonecrosis is a disease caused by reduced intraosseous blood flow to bones in the joints, which will rapidly induce joint destruction. Approximately one-third patients with severe acute respiratory syndrome (SARS) who received high cumulative doses and long treatment durations of glucocorticoids occurred osteonecrosis. Considering the similarity of SARS and COVID-19 on their pathogen, clinical characteristics, and therapeutic strategies, it is particularly desirable to investigate whether osteonecrosis will become a common sequela among convalescent COVID-19 patients. METHODS: This multi-strategy study was designed by integrating different research methods, such as meta-analysis, systematic review, and cross-sectional investigations to address above study objectives. At first, two meta-analyses were performed on the osteonecrosis incidence among SARS patients and the clinical data of glucocorticoid exposure among COVID-19 patients. Then, a systematic review of low-dosage glucocorticoid associated osteonecrosis and a cross-sectional investigation of glucocorticoid exposure of COVID-19 patients in Wuhan city of China were also conducted. Moreover, the pathogenesis, diagnosis, prevention, and treatment options for osteonecrosis patients with COVID-19 infection were further presented and discussed. RESULTS: Our meta-analysis showed that 32% of SARS patients had developed osteonecrosis after receiving glucocorticoid treatment with high dose, and our system review supported that low level glucocorticoid exposure might also lead to the occurrence of osteonecrosis. Similarly, 40% of COVID-19 patients had undergone glucocorticoid treatment according to our meta-analysis. The cross-sectional investigation in Wuhan city of China found that the average of cumulative glucocorticoid exposure level was 504 â€‹mg calculated by the dosage of methylprednisolone. Notably, a confirmed osteonecrosis case was identified from 1406 patients with COVID-19 during our cross-sectional investigation, implying that preventive management of osteonecrosis should be better started with regular clinical follow-up observation. CONCLUSION: Growing evidence of the glucocorticoid therapy for COVID-19 patients prompts us to establish risk-classification-based early screening and to introduce early prevention protocol of its associated osteonecrosis that will be of clinical significance in favor of improved prognosis of this disease. THE TRANSLATIONAL POTENTIAL OF THIS ARTICLE: To establish risk-classification-based early screening and to introduce early prevention protocol of glucocorticoid-induced osteonecrosis will be of clinical significance in favor of improved prognosis of COVID-19.

The feasibility of at-home sleep extension in adolescents and young adults: A meta-analysis and systematic review.

Insufficient sleep duration is detrimental to health and performance and is alarmingly common in adolescents and young adults. The aim of this pre-registered meta-analysis was to determine the feasibility of at-home sleep extension as a means to improve sleep duration and daytime sleepiness, and maintain or improve sleep quality and efficiency, in adolescents and young adults. Peer-reviewed journal articles and dissertations were screened to identify studies with at least five consecutive days of at-home sleep extension, pre- and post-extension measurement of sleep duration, and participants 13-30 years of age. Out of 2254 studies assessed for eligibility, 17 met review inclusion criteria - seven in adolescents and ten in young adults. At-home extension of sleep opportunity reliably increased sleep duration and sleep quality, and decreased daytime sleepiness when compared to unmanipulated sleep opportunity. These results indicate that at-home sleep extension is feasible in adolescents and young adults. However, the degree of improvement in sleep duration, sleep quality, and daytime sleepiness varied by study population and sleep extension method, which will have downstream consequences for the effectiveness of sleep extension as an experimental manipulation and intervention to improve health and performance during adolescence and young adulthood.

Risk factors and prevention strategies for the occupational exposure of medical staff during the coronavirus disease-19 pandemic (Review).

During the sudden epidemic of this novel coronavirus-induced pneumonia, a number of medical staff were infected and even succumbed to coronavirus disease-19 (COVID-19). Based on the experience of medical professionals from The Hubei 672 Orthopedics Hospital of Integrated Chinese and Western Medicine on this COVID-19 pandemic, the present review summarizes the risk factors associated with the occupational exposure of front-line medical staff. Challenges encountered include insufficient understanding, lack of early protection, environmental factors and routine procedures and the lack of adequate prevention strategies. Overcoming these challenges can potentially enhance awareness of COVID-19 prevention and control among medical staff, in addition to strengthening the personal protection of front-line medical staff, rational area layout, regular disinfection, standardization of daily procedures, reasonable scheduling and early psychological intervention. The present article may serve as a referencing point for the prevention and control of this epidemic.

Neutralizing Antibodies and Cellular Immune Responses Against SARS-CoV-2 Sustained One and a Half Years After Natural Infection.

Background: COVID-19 has caused more than 2.6 billion infections and several million deaths since its outbreak 2 years ago. We know very little about the long-term cellular immune responses and the kinetics of neutralizing antibodies (NAbs) to SARS-CoV-2 because it has emerged only recently in the human population. Methods: We collected blood samples from individuals who were from the first wave of the COVID-19 epidemic in Wuhan between December 30, 2019, and February 24, 2020. We analyzed NAbs to SARS-CoV-2 using pseudoviruses and IgG antibodies to SARS-CoV-2 spike (S) and nucleocapsid (N) protein using enzyme-linked immunosorbent assay in patients' sera and determined SARS-CoV-2-specific T-cell responses of patients with ELISpot assays. Results: We found that 91.9% (57/62) and 88.9% (40/45) of COVID-19 patients had NAbs against SARS-CoV-2 in a year (10-11 months) and one and a half years (17-18 months), respectively, after the onset of illness, indicating that NAbs against SARS-CoV-2 waned slowly and possibly persisted over a long period time. Over 80% of patients had IgG antibodies to SARS-CoV-2 S and N protein one and a half years after illness onset. Most patients also had robust memory T-cell responses against SARS-CoV-2 one and a half years after the illness. Among the patients, 95.6% (43/45) had an IFN-γ-secreting T-cell response and 93.8% (15/16) had an IL-2-secreting T-cell response. The T-cell responses to SARS-CoV-2 were positively correlated with antibodies (including neutralizing antibodies and IgG antibodies to S and N protein) in COVID-19 patients. Eighty percent (4/5) of neutralizing antibody-negative patients also had SARS-CoV-2-specific T-cell response. After long-term infection, protective immunity was independent of disease severity, sex, and age. Conclusions: We concluded that SARS-CoV-2 infection elicited a robust and persistent neutralizing antibody and memory T-cell response in COVID-19 patients, indicating that these sustained immune responses, among most SARS-CoV-2-infected people, may play a crucial role in protection against reinfection.

Adherence to cultural values and the internalization of sociocultural appearance ideals are associated with exercise dependence symptoms in Asian/Asian American men.

This study examined sociocultural correlates of exercise dependence symptoms (EDSX) in young Asian/Asian American men. We hypothesized that greater adherence to Asian cultural values would be positively associated with EDSX and that the internalization of muscularity and thinness appearance ideals would exacerbate this link. Participants included 266 Asian/Asian American men (18-30y, Mage = 24.4 ± 3.6y; MBMI = 24.2 ± 5 kg/m2) enrolled in a larger study examining disordered eating and body image concerns in ethnically/racially diverse young men. Participants completed an online survey that assessed demographics, adherence to Asian values, internalization of muscularity and thinness appearance ideals, and EDSX. After adjusting for BMI, income, education, and presence of a psychiatric diagnosis, a linear regression model indicated that adherence to Asian values was significantly and positively associated with EDSX (B = 12.13, p = .036). Neither internalization of muscularity (p = .812) nor thinness (p = .967) appearance ideals moderated this association. However, independently, both internalization of muscularity (B = 10.93, p < .001) and thinness appearance ideals (B = 7.92, p < .001) were positively associated with EDSX. The current study highlights the importance of considering cultural factors, such as adherence to traditional norms, in our investigations of EDSX in young Asian/Asian American men and the need to develop tailored interventions for young men's disordered eating symptoms. Our data also support the link between sociocultural ideals of attractiveness and young men's excessive exercise behaviors, contributing to a robust body of literature highlighting the problems with a cultural emphasis on specific body sizes and shapes.