Application of Nanotechnology in Thrombus Therapy.

A thrombus is a blood clot that forms in the lumen of an artery or vein, restricting blood flow and causing clinical symptoms. Thrombosis is associated with many life-threatening cardiovascular diseases. However, current clinical therapeutic technologies still have many problems in targeting, enrichment, penetration, and safety to meet the thrombosis treatment needs. Therefore, researchers devote themselves to developing nanosystems loaded with antithrombotic drugs to address this paradox in recent years. Herein, the existing thrombosis treatment technologies are first reviewed; and then, their advantages and disadvantages are outlined based on a brief discussion of thrombosis's definition and formation mechanism. Furthermore, the need and application cases for introducing nanotechnology are discussed, focusing on thrombus-specific targeted ligand modification technology and microenvironment-triggered responsive drug release technology. Then, nanomaterials that can be used to design antithrombotic nanotherapeutic systems are summarized. Moreover, a variety of drug delivery technologies driven by nanomotors in thrombosis therapy is also introduced. Last of all, a prospective discussion on the future development of nanotechnology for thrombosis therapy is highlighted.

The relationship between anxiety and depression with smartphone addiction among college students: The mediating effect of executive dysfunction.

Smartphone addiction symptom is increasing globally. Many studies have found that negative emotion is associated with smartphone addiction, but few explore the mediating effect of executive dysfunction. In a large-scale, cross-sectional survey, 421 Chinese college students completed measures on anxiety, depression, smartphone addiction, and executive dysfunction. We surveyed the prevalence of depression, impaired executive function, and smartphone addiction. A confirmatory factor analysis was performed on the questionnaire structure, and the mediation models were used to examine the relationship between anxiety, depression, impaired executive function, and smartphone addiction. The main finding indicated that anxiety, depression, and executive dysfunction were positively and significantly associated with smartphone addiction. Executive dysfunction plays a mediation role between anxiety and depression with smartphone addiction. Specifically, executive dysfunction completely mediates the pathway of anxiety and smartphone addiction and partly mediates the path of depression and smartphone addiction. Depression directly predicted smartphone addiction positively but anxiety did not. The sample consisted of Chinese college students, which limits generalizability and self-reported lack of objectivity. The result suggests that we should pay more attention to the mediating role of executive dysfunction between negative emotion and smartphone addiction.